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Ramipril

Generic Name: ramipril (RAM i pril)
Brand Names: Altace
Ramipril treats high blood pressure, heart failure, and improves survival after a heart attack. Learn about side effects, interactions and indications.
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Drug Information:
Ramipril (Altace) is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Ramipril is used to treat high blood pressure (hypertension) or congestive heart failure, and to improve survival after a heart attack. Ramipril may also be used for purposes not listed in this medication guide. Do not use ramipril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. You should not use ramipril if you have ever had angioedema. Do not take this medicine within 36 hours before or after taking medicine that contains sacubatril (such as Entresto). Learn more

Ramipril Side Effects

Ramipril Side Effects

In Summary

Commonly reported side effects of ramipril include: hypotension and increased cough. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ramipril: oral capsule

Warning

Oral route (Capsule; Tablet)

When pregnancy is detected, discontinue ramipril as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Along with its needed effects, ramipril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ramipril:

More common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness

Less common

  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • chills
  • cloudy urine
  • cold sweats
  • decrease in urine output or decrease in urine-concentrating ability
  • diarrhea
  • fainting
  • fast or irregular heartbeat
  • shortness of breath

Rare

  • Seizures
  • unexplained bleeding or bruising

Some side effects of ramipril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Cough

Less common

  • Nausea
  • vomiting

Rare

  • Feeling of constant movement of self or surroundings
  • muscle pain or stiffness
  • sensation of spinning
  • stomach pain
  • weight loss

For Healthcare Professionals

Applies to ramipril: oral capsule, oral tablet

General

The most common adverse reaction is hypotension.

Cardiovascular

Very common (10% or more): Hypotension (11%)

Common (1% to 10%): Angina pectoris, postural hypotension, orthostatic blood pressure decreased

Uncommon (0.1% to 1%): Symptomatic hypotension, myocardial ischemia, myocardial infarction, tachycardia, arrhythmia, palpitation, flushing

Rare (less than 0.1%): Vascular stenosis, hypoperfusion, vasculitis

Frequency not reported: Disturbed orthostatic regulation, Raynaud's phenomenon

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea, gastrointestinal inflammation, digestive disturbances, abdominal discomfort, dyspepsia

Uncommon (0.1% to 1%): Pancreatitis, pancreatic enzymes increased, abdominal pain, small bowel angioedema, gastritis, constipation, dry mouth

Rare (less than 0.1%): Glossitis

Frequency not reported: Dysphagia, gastroenteritis, increased salivation, gastric pain, aphthous stomatitis

Other

Common (1% to 10%): Fatigue, asthenia, vertigo, bronchitis, sinusitis, chest pain

Uncommon (0.1% to 1%): Peripheral edema, pyrexia, libido decreased

Rare (less than 0.1%): Conjunctivitis, hearing impaired, tinnitus

Frequency not reported: Hearing loss, edema, malaise, gynecomastia

Respiratory

Common (1% to 10%): Cough, nonproductive tickling cough, cough increased, dyspnea

Uncommon (0.1% to 1%): Bronchospasm, asthma aggravated

Frequency not reported: Eosinophilic pneumonitis, epistaxis, nasal congestion

Psychiatric

Uncommon (0.1% to 1%): Depressed mood, anxiety, nervousness, restlessness, sleep disorder

Rare (less than 0.1%): Confusional state

Frequency not reported: Depression, insomnia, disturbance in attention

Nervous system

Common (1% to 10%): Headache, dizziness, syncope

Uncommon (0.1% to 1%): Paresthesia, dysgeusia, ageusia, somnolence

Rare (less than 0.1%): Tremor, balance disorder

Frequency not reported: Smell disturbance, amnesia, convulsions, neuralgia, neuropathy, cerebral ischemia, ischemic stroke, transient ischemic attack, psychomotor skills impaired, burning sensation, parosmia

Musculoskeletal

Common (1% to 10%): Muscle spasm, myalgia

Uncommon (0.1% to 1%): Arthralgia

Frequency not reported: Arthritis

Dermatologic

Common (1% to 10%): Maculopapular rash

Uncommon (0.1% to 1%): Pruritus, hyperhidrosis

Rare (less than 0.1%): Exfoliative dermatitis, urticaria, onycholysis

Frequency not reported: Purpura, pemphigus, pemphigoid, erythema multiforme, toxic epidermal necrolysis, Stevens Johnson syndrome, sweating increased, alopecia, psoriasis aggravated, dermatitis psoriasiform, lichenoid exanthema, enanthema

Renal

Common (1% to 10%): Abnormal kidney function

Uncommon (0.1% to 1%): Renal impairment, acute renal failure

Metabolic

Common (1% to 10%): Creatinine increased, blood potassium increased

Uncommon (0.1% to 1%): Anorexia, decreased appetite, BUN increased

Frequency not reported: Weight gain, hyponatremia, loss of appetite, uric acid elevated, blood glucose elevated, blood sodium decreased

Postmarketing reports: Hypoglycemia

Genitourinary

Uncommon (0.1% to 1%): Worsening of preexisting proteinuria, urine output increased, transient erectile impotence

Frequency not reported: Proteinuria, impotence

Ocular

Uncommon (0.1% to 1%): Visual disturbance, blurred vision

Hematologic

Uncommon (0.1% to 1%): Eosinophilia, hemoglobin or hematocrit decreased

Rare (less than 0.1%): Neutropenia, agranulocytosis, white blood cell count decreased, red blood cell count decreased, platelet count decreased

Frequency not reported: Pancytopenia, hemolytic anemia, thrombocytopenia, leucopenia, bone marrow failure

Hepatic

Uncommon (0.1% to 1%): Hepatic enzymes increased, conjugated bilirubin increased

Rare (less than 0.1%): Cholestatic jaundice, hepatocellular damage

Frequency not reported: Hepatic failure, hepatitis, jaundice, acute liver failure, hepatocellular damage, cholestatic hepatitis, cytolytic hepatitis, serum bilirubin elevated

Immunologic

Uncommon (0.1% to 1%): Angioneurotic edema, angioedema

Very rare (less than 0.01%): Photosensitivity

Frequency not reported: Anaphylactic reaction, anaphylactoid reaction, apparent hypersensitivity reaction, antinuclear antibody increased

Endocrine

Frequency not reported: Syndrome of inappropriate antidiuretic hormone secretion

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ramipril