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Generic Name: pyrazinamide (peer a ZIN a mide)
Brand Name:
Physician reviewed pyrazinamide patient information - includes pyrazinamide description, dosage and directions.
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Drug Information:
Pyrazinamide is an antibiotic that fights bacteria. Pyrazinamide is used to treat tuberculosis (TB) in adults and children. Pyrazinamide must be used with other TB medicines. Tuberculosis can become resistant to treatment if pyrazinamide is used alone. Take all your medicines as prescribed by your doctor. Pyrazinamide may also be used for purposes not listed in this medication guide. You should not use pyrazinamide if you have active gout or severe liver disease. You should not use pyrazinamide if you are allergic to it, or if you have: Learn more

Pyrazinamide Side Effects

Pyrazinamide Side Effects

For the Consumer

Applies to pyrazinamide: oral tablet

Along with its needed effects, pyrazinamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pyrazinamide:

More common

  • Pain in large and small joints


  • Loss of appetite
  • pain and swelling of joints, especially big toe, ankle, and knee
  • tense, hot skin over affected joints
  • unusual tiredness or weakness
  • yellow eyes or skin

Some side effects of pyrazinamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Itching
  • skin rash

For Healthcare Professionals

Applies to pyrazinamide: oral tablet


Common (1% to 10%): Mild arthralgia, myalgia

Frequency not reported: Arthralgia


Rare (0.01% to 0.1%): Adverse effects on blood clotting mechanisms, erythrocyte vacuolation, sideroblastic anemia, thrombocytopenia

Frequency not reported: Splenomegaly


Rare (0.01% to 0.1%): Increased serum iron concentration, porphyria

Frequency not reported: Anorexia, gout/active gout


Rare (0.01% to 0.1%): Acne, photosensitivity

Frequency not reported: Pruritus, rashes, urticaria


Rare (0.01% to 0.1%): Fever

Frequency not reported: Malaise


Rare (0.01% to 0.1%): Dysuria


Rare (0.01% to 0.1%): Interstitial nephritis


Rare (0.01% to 0.1%): Erythroid hyperplasia


Frequency not reported: Clinical jaundice, hepatic failure/fatal hepatic failure, hepatic reaction, hepatomegaly, hepatotoxicity, liver tenderness, symptomless abnormality of hepatic cell function

Hepatotoxicity may be dose-related, and can occur at any time during treatment.


Frequency not reported: Aggravation of peptic ulcer, nausea, vomiting


Frequency not reported: Hypersensitivity reactions


Frequency not reported: Flushing

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Pyrazinamide