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Pylera

Generic Name: bismuth subcitrate potassium, metronidazole, and tetracycline (BIZ muth sub SIT rate poe TASS ee um, MET roe NYE da zole, TET ra SYE kleen)
Brand Names: Pylera
Pylera is used together with omeprazole to treat stomach ulcers with associated helicobacter pylori infection. Learn about side effects, interactions and indications.
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Drug Information:
Pylera contains a combination of bismuth subcitrate potassium, metronidazole, and tetracycline. Bismuth subcitrate potassium is a mineral. Metronidazole and tetracycline are antibiotics that fight bacteria in the body. Pylera is used to treat peptic ulcer (duodenal ulcer) with Helicobacter pylori infection. Pylera is usually given together with omeprazole (Prilosec). You should not use Pylera if you have severe kidney disease, or if you have taken disulfiram (Antabuse) within the past 2 weeks. Do not use Pylera if you are pregnant or breastfeeding. Using tetracycline during pregnancy could harm the unborn baby or cause permanent tooth discoloration later in the baby's life. Learn more

Pylera Side Effects

Pylera Side Effects

Note: This document contains side effect information about bismuth subcitrate potassium / metronidazole / tetracycline. Some of the dosage forms listed on this page may not apply to the brand name Pylera.

For the Consumer

Applies to bismuth subcitrate potassium/metronidazole/tetracycline: oral capsule

Warning

Oral route (Capsule)

Metronidazole has been shown to be carcinogenic in mice and rats. It is unknown whether metronidazole is associated with carcinogenicity in humans.

Along with its needed effects, bismuth subcitrate potassium/metronidazole/tetracycline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bismuth subcitrate potassium / metronidazole / tetracycline:

More common

  • Belching
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • indigestion
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore or dry throat
  • stomach discomfort, upset, or pain
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Less common

  • Back pain
  • body aches or pain
  • burning feeling in the chest or stomach
  • chest pain
  • congestion
  • dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • hoarseness
  • itching of the vagina or genital area
  • lack or loss of strength
  • lower back or side pain
  • pain during sexual intercourse
  • painful or difficult urination
  • rash with flat lesions or small raised lesions on the skin
  • sneezing
  • stuffy nose
  • tender, swollen glands in the neck
  • tenderness in the stomach area
  • thick, white vaginal discharge with no odor or with a mild odor
  • trouble with swallowing
  • voice changes

Rare

  • Bloated feeling
  • excess air or gas in the stomach or bowels
  • feeling of fullness
  • pain or tenderness around the eyes and cheekbones
  • passing gas
  • skin rash
  • tightness of the chest
  • trouble breathing

Some side effects of bismuth subcitrate potassium / metronidazole / tetracycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Black or dark tongue
  • black stools

Less common

  • Change in taste, or bad, unusual, or unpleasant aftertaste
  • dry mouth
  • fear or nervousness

For Healthcare Professionals

Applies to bismuth subcitrate potassium / metronidazole / tetracycline: oral capsule

General

The most commonly reported side effects included abnormal feces, nausea, and diarrhea.

Gastrointestinal

Very common (10% or more): Abnormal feces (up to 15.6%)

Common (1% to 10%): Nausea, diarrhea, abdominal pain, dyspepsia, constipation, dry mouth

Frequency not reported: Flatulence, glossitis, vomiting, tongue darkening, gastritis, gastroenteritis, duodenal ulcer

Postmarketing reports: Abdominal distention, eructation, flatulence, pseudomembranous colitis/Clostridium difficile colitis

Metronidazole:

Frequency not reported: Nausea, vomiting, diarrhea, abdominal pain, constipation, furry tongue, glossitis, stomatitis, dry mouth, pancreatitis

Tetracycline:

Frequency not reported: Nausea, vomiting, diarrhea, glossitis, black hairy tongue, dysphagia, enterocolitis, anogenital region inflammatory lesions/inflammatory lesions with Candida overgrowth, esophagitis, esophageal ulceration

Nervous system

Common (1% to 10%): Headache, dysgeusia, dizziness

Frequency not reported: Somnolence

Postmarketing reports: Peripheral neuropathy

Metronidazole:

Frequency not reported: Metallic taste, convulsive seizures, encephalopathy, aseptic meningitis, peripheral neuropathy, headache, syncope, dizziness, vertigo, incoordination, ataxia, dysarthria

Tetracycline:

Frequency not reported: Intracranial hypertension, pseudotumor cerebri

Other

Common (1% to 10%): Asthenia, abnormal laboratory tests

Frequency not reported: Malaise

Postmarketing reports: Fatigue, candidiasis

Metronidazole:

Frequency not reported: Candida overgrowth, fever, weakness

Tetracycline:

Frequency not reported: Tinnitus

Genitourinary

Common (1% to 10%): Vaginal infection, urine abnormality

Metronidazole:

Frequency not reported: Vaginal/vulvar dryness, dysuria, polyuria, incontinence, darkened urine, pelvic pressure, dyspareunia, proctitis

Hepatic

Common (1% to 10%): ALT increase, AST increase

Tetracycline:

Frequency not reported: Hepatotoxicity, liver failure

Dermatologic

Common (1% to 10%): Maculopapular rash

Uncommon (0.1% to 1%): Rash

Frequency not reported: Pruritus

Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS)

Metronidazole:

Frequency not reported: Urticaria, erythematous rash, pruritus

Tetracycline:

Frequency not reported: Maculopapular/erythematous rash, onycholysis, nail discoloration, exfoliative dermatitis, photosensitivity, urticaria, Henoch-Schonlein purpura, systemic lupus erythematosus exacerbation

Cardiovascular

Frequency not reported: Chest pain, tachycardia

Postmarketing reports: Chest discomfort

Metronidazole:

Frequency not reported: T-wave flattening, flushing

Tetracycline:

Frequency not reported: Pericarditis

Metabolic

Frequency not reported: Increased appetite, increased weight

Metronidazole:

Frequency not reported: Anorexia

Tetracycline:

Frequency not reported: Anorexia

Musculoskeletal

Frequency not reported: Back pain, increased blood creatinine phosphokinase, myalgia

Metronidazole:

Frequency not reported: Joint pain

Tetracycline:

Frequency not reported: Myasthenic syndrome

Ocular

Frequency not reported: Visual disturbance

Metronidazole:

Frequency not reported: Optic neuropathy

Hematologic

Metronidazole:

Frequency not reported: Reversible neutropenia/leukopenia, reversible thrombocytopenia

Tetracycline:

Frequency not reported: Hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, neutropenia, eosinophilia

Renal

Metronidazole:

Frequency not reported: Cystitis

Tetracycline:

Frequency not reported: Increased blood urea nitrogen

Psychiatric

Frequency not reported: Anxiety

Metronidazole:

Frequency not reported: Confusion, irritability, depression, insomnia, decreased libido

Hypersensitivity

Tetracycline:

Frequency not reported: Angioedema, anaphylaxis

Immunologic

Tetracycline:

Frequency not reported: Serum sickness-like reaction

Respiratory

Metronidazole:

Frequency not reported: Nasal congestion

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Pylera