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Generic Name: dornase alfa (inhalation) (DOOR nase AL fa)
Brand Names: Pulmozyme
Pulmozyme is used to improve lung function in people with cystic fibrosis. Learn about side effects, interactions and indications.
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Drug Information:
Pulmozyme is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis. Pulmozyme is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections. Pulmozyme may also be used for purposes other than those listed in this medication guide. Ampules of Pulmozyme do not contain a preservative. Once opened, the entire contents of the ampule must be used or discarded. Before using Pulmozyme, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medicines. You may require a dosage adjustment or special monitoring during your treatment. Learn more

Pulmozyme Side Effects

Pulmozyme Side Effects

Note: This document contains side effect information about dornase alfa. Some of the dosage forms listed on this page may not apply to the brand name Pulmozyme.

In Summary

Common side effects of Pulmozyme include: transient skin rash and voice disorder. Other side effects include: laryngitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dornase alfa: inhalation solution

Along with its needed effects, dornase alfa (the active ingredient contained in Pulmozyme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dornase alfa:

More common

  • Body aches or pain
  • chest pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender, swollen glands in the neck
  • trouble breathing
  • trouble swallowing
  • voice changes

Some side effects of dornase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • rash
  • sneezing
  • stomach discomfort, upset, or pain
  • stuffy nose

Less common

  • Burning, dry, or itching eyes
  • discharge or excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

For Healthcare Professionals

Applies to dornase alfa: inhalation solution


Very common (10% or more): Rash (up to 12%)

Rare (less than 0.1%): Urticaria


Very common (10% or more): Chest pain (up to 25%)


Very common (10% or more): Fever (up to 32%), voice alteration (up to 18%)


Very common (10% or more): Pharyngitis (up to 40%), rhinitis (up to 30%), dyspnea (up to 17%)

Common (1% to 10%): Laryngitis, Force Vita Capacity (FVC) decreased of 10% of predicted

Rare (less than 0.1%): Chest pain (pleuritic/non-cardiac), dysphonia, pulmonary function tests decreased


Common (1% to 10%): Dyspepsia


Common (1% to 10%): Development of serum antibodies (2% to 4%)


Common (1% to 10%): Conjunctivitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Pulmozyme