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Provigil

Generic Name: modafinil (moe DAF i nil)
Brand Names: Provigil
Provigil is used to treat sleepiness caused by sleep apnea or narcolepsy. Learn about side effects, interactions and indications.
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Drug Information:
Provigil (modafinil) is a medication that promotes wakefulness. It is thought to work by altering the natural chemicals (neurotransmitters) in the brain. Provigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder. Provigil may also be used for purposes not listed in this medication guide. You should not use Provigil if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil). Provigil can cause skin reactions that may be severe enough to need treatment in a hospital. Stop taking this medicine and get emergency medical help if you have a skin rash or hives, blisters or peeling, mouth sores, trouble breathing or swallowing, fever, swelling in your legs, dark urine, yellowing of your skin or eyes, or swelling in your face. Learn more

Provigil Side Effects

Provigil Side Effects

Note: This document contains side effect information about modafinil. Some of the dosage forms listed on this page may not apply to the brand name Provigil.

In Summary

Common side effects of Provigil include: headache and nausea. Other side effects include: anorexia and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to modafinil: oral tablet

Along with its needed effects, modafinil (the active ingredient contained in Provigil) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking modafinil:

Less common

  • Black, tarry stools
  • blurred vision or other vision changes
  • chest pain
  • chills or fever
  • clumsiness or unsteadiness
  • confusion
  • dizziness or fainting
  • increased thirst and urination
  • mental depression
  • problems with memory
  • rapidly changing moods
  • shortness of breath
  • sore throat
  • trembling or shaking
  • trouble in urinating
  • uncontrolled movements of the face, mouth, or tongue
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking modafinil:

Symptoms of overdose

  • Agitation or excitement
  • fast or pounding heartbeat
  • increased blood pressure
  • trouble with sleeping

Some side effects of modafinil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Anxiety
  • headache
  • nausea
  • nervousness

Less common

  • Back pain
  • belching
  • decrease in appetite
  • diarrhea
  • difficulty having a bowel movement
  • dryness of the mouth
  • dryness of the skin
  • feeling of constant movement of self or surroundings
  • flushing or redness of the skin
  • heartburn
  • indigestion
  • muscle stiffness
  • sores, ulcers, or white spots on the lips or in the mouth
  • sour stomach
  • stomach discomfort upset or pain
  • stuffy or runny nose
  • swelling
  • tingling, burning, or prickling sensations in the skin
  • vomiting

For Healthcare Professionals

Applies to modafinil: oral tablet

Nervous system

Very common (10% or more): Headache (up to 34%)

Common (1% to 10%): Dizziness, paresthesia, somnolence, tremor, taste perversion, vertigo, oro-facial dyskinesia, hyperkinesia, hypertonia

Uncommon (0.1% to 1%): Amnesia, migraine, CNS stimulation, incoordination, movement disorder, speech disorder, hypoesthesia

Very rare (less than 0.01%): Tardive dyskinesia, convulsions

Frequency not reported: Cataplexy

Gastrointestinal

Very common (10% or more): Nausea (up to 11%)

Common (1% to 10%): Diarrhea, dry mouth, dyspepsia, constipation, flatulence, mouth ulceration, abdominal pain

Uncommon (0.1% to 1%): Reflux, vomiting, dysphagia, glossitis

Frequency not reported: Periodontal abscess

General

The development of adverse reactions (skin and hypersensitivity, central nervous system [CNS], psychiatric, and cardiovascular) appear to be related to higher doses; cardiovascular and CNS reactions increase significantly after a total daily dose of more than 400 mg.

Cardiovascular

Common (1% to 10%): Palpitations, chest pain, hypertension, tachycardia, vasodilation

Uncommon (0.1% to 1%): Extrasystoles, arrhythmia, bradycardia, hypotension, transient ischemic T-wave changes, abnormal ECG

Rare (less than 0.1%): Increased blood pressure

Very rare (less than 0.01%): Ischemic heart disease

Frequency not reported: Asystole

Dermatologic

Common (1% to 10%): Sweating, herpes simplex

Uncommon (0.1% to 1%): Rash, acne, pruritus

Rare (less than 0.1%): Eczema

Frequency not reported: Ecchymosis, serious skin reactions (including Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Rash with Eosinophilia and Systemic Symptoms, erythema multiforme)

Genitourinary

Common (1% to 10%): Urine abnormality, hematuria, pyuria

Uncommon (0.1% to 1%): Urinary frequency

Rare (less than 0.1%): Foul urine odor

Frequency not reported: Urinary tract infection

Hematologic

Common (1% to 10%): Eosinophilia

Uncommon (0.1% to 1%): Leukopenia

Postmarketing reports: Agranulocytosis

Hepatic

Common (1% to 10%): Increased gamma-glutamyltransferase, increased alkaline phosphatase, abnormal liver function, elevated liver enzymes, eosinophilia

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reaction (e.g., hayfever)

Very rare (less than 0.01%): Multi-organ hypersensitivity reactions, urticaria (hives), angioedema, anaphylaxis

Metabolic

Common (1% to 10%): Anorexia, thirst, decreased appetite

Uncommon (0.1% to 1%): Hypercholesterolemia, hyperglycemia, diabetes mellitus, increased appetite, increased weight, decreased weight

Musculoskeletal

Common (1% to 10%): Back pain, neck rigidity

Uncommon (0.1% to 1%): Neck pain, myalgia, myasthenia, leg cramps, arthralgia, twitch, arthritis

Rare (less than 0.1%): Muscle weakness

Ocular

Common (1% to 10%): Abnormal vision, blurred vision, amblyopia, eye pain

Uncommon (0.1% to 1%): Dry eye

Frequency not reported: Conjunctivitis

Other

Common (1% to 10%): Chills, edema, asthenia, flu syndrome, thirst

Uncommon (0.1% to 1%): Peripheral edema, menstrual disorder

Rare (less than 0.1%): Tolerance, aggravated condition, malaise, fatigue

Frequency not reported: Infection, pain, accidental injury, fever, viral infection, tooth disorder, hypothermia, ear pain

Psychiatric

Common (1% to 10%): Insomnia, anxiety, depression, agitation, nervousness, confusion, emotional lability, abnormal thinking, irritability

Uncommon (0.1% to 1%): Sleep disorder, decreased libido, hostility, depersonalization, personality disorder, abnormal dreams, aggression, suicidal ideation, psychomotor hyperactivity

Rare (less than 0.1%): Hallucinations, mania, psychosis, delusions, suicide attempt

Respiratory

Common (1% to 10%): Rhinitis, pharyngitis, lung disorder, asthma, epistaxis

Uncommon (0.1% to 1%): Sinusitis, dyspnea, increased cough

Frequency not reported: Bronchitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Provigil