Note: This document contains side effect information about dinoprostone topical. Some of the dosage forms listed on this page may not apply to the brand name Prostin E2.
Applies to dinoprostone topical: vaginal gel/jelly, vaginal insert extended release, vaginal suppository
Vaginal route (Suppository)
Dinoprostone should be used with strict adherence to recommended dosages and only by medically trained personnel in a hospital setting that can provide immediate intensive care and acute surgical facilities.
Along with its needed effects, dinoprostone topical (the active ingredient contained in Prostin E2) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dinoprostone topical:
Less common or rare
Some side effects of dinoprostone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare
This procedure may still result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if any of the following side effects occur while taking dinoprostone topical:
Applies to dinoprostone topical: vaginal gel, vaginal insert, vaginal suppository
Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, abdominal pain
Very common (10% or more): Any fetal heart rate abnormality
Frequency not reported: Hearing impairment, neonatal distress, neonatal death, stillbirths, low Apgar score
Common (1% to 10%): Hypotension, bradycardia
Frequency not reported: Flushing or hot flashes, chest pain, cardiac arrhythmia
Uncommon (0.1% to 1%): Fever
Frequency not reported: Headache, dizziness, weakness, tremor, paresthesia
Rare (0.01% to 0.1%): Postpartum disseminated intravascular coagulation
Frequency not reported: Elevated WBC
Frequency not reported: Dehydration
Frequency not reported: Back pain, joint inflammation or pain new or exacerbated, muscle cramp or pain, nocturnal leg cramps
Frequency not reported: Dyspnea, coughing, pharyngitis, laryngitis, wheezing, tightness in chest, pharyngitis, laryngitis
Frequency not reported: Rash, diaphoresis, skin discoloration
Frequency not reported: Blurred vision, eye pain
Frequency not reported: Anaphylactic reactions (including anaphylactic shock)
Common (1% to 10%): Uterine hyperstimulation (with or without fetal distress), fetal distress without uterine hyperstimulation, warm feeling in vagina
Frequency not reported: Uterine hypertonus, uterine rupture, placenta abruptio, rapid cervical dilatation, vaginal pain, vaginal irritation, vaginitis or vulvitis, breast tenderness, vaginismus, genital edema, transient vasovagal symptoms (flushing, shivering, headache, dizziness)
Frequency not reported: Tension
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Prostin E2