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Generic Name: trimethoprim (trye METH oh prim)
Brand Name: Primsol
Physician reviewed Primsol patient information - includes Primsol description, dosage and directions.
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Drug Information:
Primsol is an antibiotic that is used to treat bladder or kidney infections, or ear infections caused by certain bacteria. Primsol may also be used for purposes not listed in this medication guide. You should not use Primsol if you have anemia caused by a folate (folic acid) deficiency. You should not use Primsol if you are allergic to it, or if you have: anemia (low red blood cells) caused by a folate (folic acid) deficiency. Primsol is not approved for use by anyone younger than 2 months old. This medicine should not be used to treat an ear infection in a child younger than 6 months old. Learn more

Primsol Side Effects

Primsol Side Effects

Note: This document contains side effect information about trimethoprim. Some of the dosage forms listed on this page may not apply to the brand name Primsol.

For the Consumer

Applies to trimethoprim: oral solution, oral tablet

Along with its needed effects, trimethoprim (the active ingredient contained in Primsol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trimethoprim:

Less common

  • Skin rash or itching


  • Black, tarry stools
  • blood in urine or stools
  • bluish fingernails, lips, or skin
  • changes in facial skin color
  • chills
  • difficult breathing or shortness of breath
  • fever with or without chills
  • general feeling of discomfort or illness
  • headache
  • joint or muscle pain
  • nausea
  • neck stiffness
  • pale skin
  • pinpoint red spots on skin
  • redness, blistering, burning, tenderness, peeling, or loosening of skin or mucous membranes
  • redness, swelling, or soreness of tongue
  • red skin lesions, often with a purple center
  • sore throat
  • swelling
  • thickened or scaly skin
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of trimethoprim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Diarrhea
  • loss of appetite
  • nausea or vomiting
  • stomach cramps or pain

For Healthcare Professionals

Applies to trimethoprim: compounding powder, oral solution, oral tablet


Common (1% to 10%): Rash (e.g., maculopapular, morbilliform, pruritic), pruritus

Rare (less than 0.1%): Photosensitivity, angioedema, erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis (Lyell Syndrome

Frequency not reported: Exfoliative dermatitis, urticaria


Common (1% to 10%): Epigastric distress, nausea, vomiting, glossitis, abdominal pain, sore mouth

Frequency not reported: Pseudomembranous colitis, Clostridium difficile associated diarrhea


Frequency not reported: Thrombocytopenia, leukopenia, neutropenia, megaloblastic anemia, methemoglobinemia


Rare (less than 0.1%): Cholestatic jaundice

Frequency not reported: ALT and AST elevations, elevated bilirubin


Rare (less than 0.1%): Anaphylaxis


Frequency not reported: Hyperkalemia, hyponatremia


Frequency not reported: Myalgia

Nervous system

Rare (less than 0.1%): Aseptic meningitis, headache


Frequency not reported: Fever


Frequency not reported: Increased BUN, increased serum creatinine

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Primsol