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Preparation h

Generic Name: Glycerin and Lidocaine (GLIS er in & LYE doe kane)
Brand Name: Preparation H, RectiCare
Easy-to-read patient leaflet for Preparation H (Glycerin and Lidocaine). Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Preparation H (glycerin and lidocaine) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Preparation H (glycerin and lidocaine) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Preparation h Side Effects

Lidocaine topical Side Effects

For the Consumer

Applies to lidocaine topical: topical application cream, topical application gel/jelly, topical application lotion, topical application ointment, topical application patch extended release, topical application powder, topical application solution, topical application spray, topical application swab

Warning

Topical application route (Solution)

Seizures, cardiopulmonary arrest, and death have been reported in patients under 3-years-old when lidocaine solution 2% was not administered according to dosing and administration recommendations. This drug should not be used for teething pain and only be administered to patients under 3-years-old when absolutely necessary.

Along with its needed effects, lidocaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lidocaine topical:

Rare

  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cough
  • cracked, dry, or scaly skin
  • fast heartbeat
  • fever
  • hives or welts, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing

Incidence not known

  • Blistering, bruising, burning, discoloration, itching, redness, or swelling at the application site
  • blurred vision
  • chest pain or discomfort
  • cold, clammy, or pale skin
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness or dizziness
  • false or unusual sense of well-being
  • fear or nervousness
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • no blood pressure or pulse
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • slow heart rate
  • slow or irregular heartbeat
  • stopping of the heart
  • trembling or shaking of the hands or feet
  • twitching
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Some side effects of lidocaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • cold or numbness
  • confusion about identity, place, and time
  • continuing ringing or buzzing or other unexplained noise in the ears
  • double vision
  • headache
  • hearing loss
  • heat sensation
  • lack or loss of strength
  • metallic taste
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lidocaine topical: intradermal device, mucous membrane solution, mucous membrane spray, topical cream, topical film, topical gel, topical gel with applicator, topical kit, topical liquid, topical lotion, topical ointment, topical solution, topical spray, topical stick

General

The most common adverse events were administration site reactions: burning, dermatitis, erythema, pruritus, rash, skin irritation, and vesicles.

Dermatologic

Very common (10% or more): Erythema (up to 67.3%), petechiae (up to 46.4%)

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Skin lesion, skin injury

Frequency not reported: Flushing, cutaneous lesions, urticaria, dermatitis

Local

Very common (10% or more): Administration site reactions

Common (1% to 10%): Irritation, redness, itching, application site erythema, application site burning, application site pain, application site pruritus, edema

Uncommon (0.1% to 1%): Venipuncture site hemorrhage, burning sensation

Frequency not reported: Locus of abnormal sensation, paleness (pallor or blanching), alteration in temperature sensation, blisters, bruising, depigmentation, dermatitis, discoloration, exfoliation, papules, petechiae, vesicles, application site dermatitis, application site vesicles, skin irritation

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness

Frequency not reported: Lightheadedness, nervousness, apprehension, euphoria, confusion, drowsiness, tinnitus, nystagmus, headache, nausea, vomiting, sensations of heat, cold or numbness, twitching, tremors, paraesthesia, convulsions, unconsciousness, respiratory depression and arrest, pain and/or dysesthesia in the buttocks or legs, unconsciousness

Postmarketing reports: Headache, hyperesthesia, hypoesthesia, lightheadedness, metallic taste, somnolence, taste alteration

Gastrointestinal

Common (1% to 10%): Nausea, vomiting

Immunologic

Common (1% to 10%): Nasopharyngitis

Hypersensitivity

Very rare (less than 0.01%): Anaphylactic reaction, hypersensitivity

Frequency not reported: Anaphylactoid reactions, anaphylactic shock, angioedema, bronchospasm, shock, dyspnea, laryngospasm

Cardiovascular

Frequency not reported: Bradycardia, hypotension, arrhythmia, cardiovascular collapse, cardiac arrest, AV block, myocardial depression

Hematologic

Frequency not reported: Methemoglobinemia

Ocular

Frequency not reported: Corneal irritation, blurred or double vision

Postmarketing reports: Visual disturbances

Respiratory

Rare (less than 0.1%): Endotracheal tube occlusion

Frequency not reported: Sore throat, hoarseness, loss of voice

Psychiatric

Frequency not reported: Confusion, psychosis, disorientation, dizziness

Other

Postmarketing reports: Open wound, asthenia, pain exacerbated

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Preparation H