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Generic Name: polymyxin B and trimethoprim ophthalmic (POL ee MIX in B and try METH oh prim off THAL mik)
Brand Name: Polytrim
Physician reviewed Polytrim patient information - includes Polytrim description, dosage and directions.
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Drug Information:
Polymyxin B and trimethoprim are antibiotics that fight bacteria in the body. Polytrim (for use in the eyes) is a combination medicine used to treat eye infections caused by bacteria. Polytrim may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use Polytrim if you are allergic to polymyxin B or trimethoprim. Learn more

Polytrim Side Effects

Polytrim Side Effects

Note: This document contains side effect information about polymyxin b / trimethoprim ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Polytrim.

For the Consumer

Applies to polymyxin b/trimethoprim ophthalmic: ophthalmic solution

Along with its needed effects, polymyxin b/trimethoprim ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking polymyxin b / trimethoprim ophthalmic:

More common

  • Increased redness, burning, stinging, or itching of the eye

Incidence not known

  • Blurred vision
  • change in color vision
  • difficulty seeing at night
  • increased sensitivity of the eyes to sunlight
  • increased tearing
  • rash around the eye
  • swelling of the eyelid

For Healthcare Professionals

Applies to polymyxin b / trimethoprim ophthalmic: ophthalmic solution


Ocular side effects are the most common, and include local irritation, increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use.


Hypersensitivity reactions have included lid edema, itching, increased redness, tearing, and/or circumocular rash.


Dermatologic side effects associated with oral trimethoprim have included photosensitivity.

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Polytrim