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Plan b one-step

Generic Name: levonorgestrel emergency contraceptive (LEE voe nor jes trel)
Brand Names: EContra EZ,Fallback Solo, My Way, Next Choice, Opcicon One-Step, Plan B One-Step, React
Plan B (levonorgestrel) is used to prevent pregnancy after unprotected sex or failure of other forms of birth control. Includes Plan B side effects, interactions and indications.
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Drug Information:
Plan B (levonorgestrel) is a female hormone that can cause changes in your cervix, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. Plan B One-Step is used to prevent pregnancy after unprotected sex or failure of other forms of birth control (such as condom breakage, or missing 2 or more birth control pills). Plan B One-Step is a backup method of preventing pregnancy and should not be used as regular birth control. Do not use Plan B One-Step if you are already pregnant. Levonorgestrel will not terminate a pregnancy that has already begun (the fertilized egg has attached to the uterus). Learn more

Plan b one-step Side Effects

Plan B Side Effects

Note: This document contains side effect information about levonorgestrel. Some of the dosage forms listed on this page may not apply to the brand name Plan B.

For the Consumer

Applies to levonorgestrel: oral tablet

Other dosage forms:

  • intrauterine insert extended release

Along with its needed effects, levonorgestrel (the active ingredient contained in Plan B) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levonorgestrel:

More common

  • Heavy or light menstrual bleeding

Incidence not known

  • Absent missed or irregular menstrual periods
  • cramps
  • irregular menstruation
  • pain
  • pain in the pelvis
  • stopping of menstrual bleeding

Some side effects of levonorgestrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • dizziness
  • headache
  • nausea
  • tenderness of the breasts
  • unusual tiredness or weakness
  • vomiting

Less common

  • Diarrhea

For Healthcare Professionals

Applies to levonorgestrel: intrauterine device, oral tablet, subcutaneous implant


The most commonly reported adverse effects are alterations of menstrual bleeding patterns, nausea, abdominal/pelvic pain, headache/migraine, dizziness, fatigue, amenorrhea, ovarian cysts, genital discharge, acne/seborrhea, breast tenderness, and vulvovaginitis.


Very common (10% or more): Irregular menstrual bleeding (67%), infrequent menstrual bleeding (up to 57%), ovarian cyst (31.2%), menstrual changes (up to 31.9%), decreased uterine bleeding (23.4%), prolonged menstrual bleeding (22%), vulvovaginitis (20.2%), amenorrhea (18.4%), genital discharge (up to 14.9%), heavier menstrual bleeding (13.8%),vaginal infections (13.6%), vulvovaginal infections (13.3%), lighter menstrual bleeding (12.5%), increased scheduled uterine bleeding (11.9%), breast tenderness (10.7%)

Common (1% to 10%): Dysmenorrhea, breast pain/discomfort, upper genital tract infection, genital tract bleeding, pelvic inflammatory disease, endometritis, dyspareunia, pelvic discomfort/pain, delay of menses more than 7 days, vaginal discharge, bleeding not related to menses

Uncommon (0.1% to 1%): Uterine spasm, cervicitis/Papanicolaou smear normal class II, change in vaginal secretion

Rare (less than 0.1%): Uterine perforation

Frequency not reported: Breast enlargement, vaginal candidiasis, changes in cervical erosion, changes in cervical secretion, ectopic pregnancy

Postmarketing reports: Oligomenorrhea, irregular menstruation


Very common (10% or more): Nausea (up to 23.1%), abdominal/pelvic pain (up to 22.6%)

Common (1% to 10%): Diarrhea, vomiting

Uncommon (0.1% to 1%): Abdominal distension

Frequency not reported: Bloating, abdominal cramps


Very common (10% or more): Fatigue (16.9%)

Common (1% to 10%): Partial/complete IUS expulsion, weight increased

Uncommon (0.1% to 1%): Edema, change in body weight

Very rare (less than 0.01%): Face edema

Frequency not reported: Decreased weight, sepsis, group A streptococcal sepsis

Postmarketing reports: IUS breakage, procedural bleeding

Nervous system

Very common (10% or more): Headache (up to 16.8%), dizziness (11.2%)

Common (1% to 10%): Migraine

Postmarketing reports: Stroke, syncope, IUS insertion related vasovagal reaction or seizure


Common (1% to 10%): Depression/depressed mood, mood changes, mood swings, decreased libido, nervousness

Frequency not reported: Changes in libido


Very common (10% or more): Acne/seborrhea (15%)

Common (1% to 10%): Alopecia, hirsutism

Uncommon (0.1% to 1%): Pruritus, eczema, pigmentation changes/hyperpigmentation

Rare (less than 0.1%): Rash, urticaria

Frequency not reported: Chloasma, melasma

Postmarketing reports: Angioedema


Postmarketing reports: Increased blood pressure, arterial/venous thrombotic events, pulmonary emboli, deep vein thrombosis, stroke


Common (1% to 10%): Back pain


Frequency not reported: Benign/malignant liver tumors

Postmarketing reports: Breast cancer


Frequency not reported: Contact lens intolerance


Frequency not reported: Diabetes mellitus


Frequency not reported: Allergic reaction

Postmarketing reports: Hypersensitivity reactions

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Plan B One-step