Note: This document contains side effect information about famotidine. Some of the dosage forms listed on this page may not apply to the brand name Pepcid.
Applies to famotidine: oral powder for suspension, oral tablet
Along with its needed effects, famotidine (the active ingredient contained in Pepcid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking famotidine:
Incidence not known
Some side effects of famotidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to famotidine: compounding powder, intravenous solution, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet disintegrating
The most commonly reported side effects include headache, dizziness, constipation, and diarrhea.
Common (1% to 10%): Constipation, diarrhea
Uncommon (0.1% to 1%): Nausea, vomiting, flatulence, dry mouth, abdominal discomfort or distension
Convulsions occurred in patients with renal dysfunction.
Common (1% to 10%): Headache, dizziness
Very rare (less than 0.01%): Paresthesia, somnolence, epileptic seizures, convulsion
Frequency not reported: Grand mal seizure, taste disorder
Uncommon (0.1% to 1%): Rash, pruritus
Rare (0.01% to 0.1%): Urticaria, angioneurotic edema
Very rare (less than 0.01%): Alopecia, severe skin reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, epidermal necrolysis
Frequency not reported: Acne, dry skin, flushing
Uncommon (0.1% to 1%): Fatigue
Frequency not reported: Asthenia, fatigue, facial/orbital edema, tinnitus
Uncommon (0.1% to 1%): Loss of appetite
Frequency not reported: Anorexia
Rare (0.01% to 0.1%): Thrombocytopenia, leukopenia, agranulocytosis, pancytopenia
Frequency not reported: Neutropenia
Rare (0.01% to 0.1%): Intrahepatic cholestasis, jaundice, increased liver enzyme abnormalities (transaminases, gamma GT, alkaline phosphatase, bilirubin)
Frequency not reported: Cholestatic jaundice, hepatitis
Rare (0.01% to 0.1%): Hypersensitivity reactions, anaphylaxis
Rare (0.01% to 0.1%): Bronchospasm
Frequency not reported: Interstitial pneumonia
Rare (0.01% to 0.1%): Arthralgia
Very rare (less than 0.01%): Muscle cramps
Frequency not reported: Rhabdomyolysis, musculoskeletal pain
When patients obtained follow-up, psychic disturbances were found to be reversible.
Very rare (less than 0.01%): Hallucinations, disorientation, confusion, anxiety, agitation, depression, reduced libido, insomnia
Frequency not reported: Psychic disturbances
QT interval prolongation occurred in patients with renal dysfunction.
Very rare (less than 0.01%): Chest tightness, prolonged QT interval
Frequency not reported: Arrhythmia, atrioventricular block, palpitation
Very rare (less than 0.01%): Impotence
Frequency not reported: Conjunctival injection
Frequency not reported: Gynecomastia
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Pepcid