Please wait...


Generic Name: apremilast (a PRE mi last)
Brand Names: Otezla
Otezla (apremilast) is used to treat psoriatic arthritis, plaque psoriasis, and oral ulcers associated with Behçet's disease. Includes Otezla side effects, interactions and indications.
  • Prescription Settings

Prices and coupons of Otezla

Current Location: 20149 (Ashburn)
Change Location?

Enter your zip code

Please wait while the prices are loaded...

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
Otezla (apremilast) inhibits an enzyme within your immune system that can affect certain cells and contribute to inflammation in the body. Otezla is used to treat the symptoms of active psoriatic arthritis in adults. Otezla can relieve tenderness and swelling in and around the joints, but this medicine is not a cure for psoriatic arthritis. Otezla is used to treat moderate to severe plaque psoriasis in people who may also receive phototherapy or other treatments for psoriasis. Otezla is also used to treat adults with oral ulcers associated with Behçet’s Disease. Learn more

Otezla Side Effects

Otezla Side Effects

Note: This document contains side effect information about apremilast. Some of the dosage forms listed on this page may not apply to the brand name Otezla.

In Summary

Common side effects of Otezla include: weight loss. Other side effects include: diarrhea, headache, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to apremilast: oral tablet

Along with its needed effects, apremilast (the active ingredient contained in Otezla) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking apremilast:


  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • thoughts of killing oneself
  • tiredness
  • trouble concentrating
  • trouble sleeping

Incidence not known

  • Fast heartbeat
  • fever
  • hives, itching, rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • weight loss

Some side effects of apremilast may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • chills
  • cough
  • diarrhea
  • ear congestion
  • headache
  • headache, severe and throbbing
  • loss of voice
  • nausea
  • sneezing
  • sore throat
  • stuffy or runny nose

Less common

  • Back pain
  • belching
  • burning, itching, pain in the hairy areas, pus at the root of the hair
  • decreased appetite
  • heartburn
  • indigestion
  • muscle aches
  • stomach discomfort, upset, or pain
  • upper abdominal or stomach pain
  • vomiting

For Healthcare Professionals

Applies to apremilast: oral tablet


The most commonly reported side effects included diarrhea, headache, and nausea.


Frequency not reported: Hypersensitivity


Common (1% to 10%): Diarrhea, nausea, vomiting, upper abdominal pain

Frequency not reported: Frequent bowel movement, gastroesophageal reflux disease, dyspepsia


Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis

Frequency not reported: Cough


Frequency not reported: Rash


Frequency not reported: Weight decrease, decreased appetite

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Migraine

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Otezla