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Osmoprep

Generic Name: sodium biphosphate and sodium phosphate (oral) (SOE dee um bye FOS foe nate and SOE dee um FOS fate)
Brand Names: OsmoPrep
OsmoPrep is used to treat constipation and to clean the bowel. Learn about side effects, interactions and indications.
  • Prescription Settings

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Drug Information:
OsmoPrep tablets contain a combination of sodium biphosphate and sodium phosphate, both are forms of phosphorus, which is a naturally occurring substance that is important in every cell in the body. OsmoPrep is used in adults to treat constipation and to clean the bowel before a colonoscopy. OsmoPrep cleans your colon by causing you to have diarrhea. Using OsmoPrep to clean your colon helps your doctor see the inside of your colon more clearly during the colonoscopy. You should not use OsmoPrep if you have kidney disease, a bowel obstruction, a perforated bowel, colitis or toxic megacolon, or a history of gastric bypass surgery or stomach stapling. Learn more

Osmoprep Side Effects

OsmoPrep Side Effects

Note: This document contains side effect information about sodium biphosphate / sodium phosphate. Some of the dosage forms listed on this page may not apply to the brand name OsmoPrep.

For the Consumer

Applies to sodium biphosphate / sodium phosphate: oral solution, oral tablet

Other dosage forms:

  • rectal enema

Warning

Oral route (Tablet)

Acute phosphate nephropathy has been reported in association with the use of oral sodium phosphate products, some cases resulting in permanent impairment of renal function, including cases requiring long-term dialysis. Risk factors for developing acute phosphate nephropathy include increased age, hypovolemia, renal impairment, bowel obstruction, or active colitis. Use of medications that may impair renal perfusion or function may also increase risk. These include diuretics, ACE inhibitors, angiotensin receptor blockers (ARBs), and possibly NSAIDs. However, cases have occurred in patients with no identifiable risk factors. It is important to use the dose and dosing regimen as recommended (pm/am split dose)..

Along with its needed effects, sodium biphosphate / sodium phosphate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium biphosphate / sodium phosphate:

More common

  • Abdominal or stomach pain
  • bloating
  • nausea
  • vomiting

Incidence not known

  • Agitation
  • bloody or cloudy urine
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • coma
  • confusion
  • cough
  • decreased urine output
  • depression
  • difficult or labored breathing
  • difficult or painful urination
  • difficulty with swallowing
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • hostility
  • irritability
  • lethargy
  • muscle twitching
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • redness of the skin
  • seizures
  • skin rash, hives or welts, or itching
  • stupor
  • swelling of the face, ankles, or hands
  • tightness in the chest
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking sodium biphosphate / sodium phosphate:

Symptoms of overdose

  • Abdominal or stomach cramps
  • blurred vision
  • chest pain or discomfort
  • decreased frequency of urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • increase in heart rate
  • increased thirst
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pain
  • pounding or rapid pulse
  • rapid breathing
  • restlessness
  • sunken eyes
  • sweating
  • tremor
  • weakness
  • weight gain
  • wrinkled skin

For Healthcare Professionals

Applies to sodium biphosphate / sodium phosphate: oral solution, oral tablet, rectal enema

General

The most common adverse events were abdominal bloating, nausea, abdominal pain, and vomiting.

Gastrointestinal

Very common (10% or more): Bloating (39%), nausea (37%), abdominal pain (24%), vomiting (10%)

Renal

Postmarketing reports: Renal impairment, increased blood urea nitrogen (BUN), increased creatinine, acute renal failure, acute phosphate nephropathy, nephrocalcinosis, renal tubular necrosis

Nervous system

Postmarketing reports: Seizures

Cardiovascular

Postmarketing reports: Arrhythmias

Hypersensitivity

Postmarketing reports: Hypersensitivity reactions (including anaphylaxis, rash, pruritus, urticaria, throat tightness, bronchospasm, dyspnea, pharyngeal edema, dysphagia, paresthesia, swelling of the lips and tongue, and facial swelling)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Osmoprep