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Osmolex er

Generic Name: amantadine (a MAN ta deen)
Brand Name: Gocovri, Osmolex ER
Physician reviewed Osmolex ER patient information - includes Osmolex ER description, dosage and directions.
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Drug Information:
Osmolex ER is an antiviral medicine that blocks the actions of viruses in your body. Osmolex ER is used to treat or prevent influenza A in adults and children. This medicine may not be effective during every flu season because certain strains of the virus may be resistant to Osmolex ER. This medicine should not be used in place of getting a yearly flu shot. The Centers for Disease Control recommends an annual flu shot to help protect you each year from new strains of influenza virus. Osmolex ER is also used to treat Parkinson's disease and "Parkinson-like" symptoms such as stiffness or tremors, shaking, and repetitive uncontrolled muscle movements that may be caused by the use of certain drugs. Learn more

Osmolex er Side Effects

Osmolex ER Side Effects

Note: This document contains side effect information about amantadine. Some of the dosage forms listed on this page may not apply to the brand name Osmolex ER.

For the Consumer

Applies to amantadine: oral capsule, oral capsule extended release, oral capsule liquid filled, oral syrup, oral tablet, oral tablet extended release

Along with its needed effects, amantadine (the active ingredient contained in Osmolex ER) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amantadine:

More common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • confusion
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • fainting
  • falls
  • frequent urge to urinate
  • lower back or side pain
  • seeing, hearing, or feeling things that are not there
  • swelling of the hands, feet, or lower legs

Less common

  • Inability to move the eyes
  • increased blinking or spasms of the eyelid
  • muscle spasm
  • sticking out of the tongue
  • troubled breathing, speaking, or swallowing
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions

Rare

  • Chills
  • decreased vision or any change in vision
  • difficulty in coordination
  • fever
  • increased blood pressure
  • increase in body movements
  • irritation and swelling of the eye
  • loss of memory
  • mental depression
  • seizures
  • severe mood or mental changes
  • skin rash
  • slurred speech
  • sore throat
  • thoughts of suicide or attempts at suicide

Some side effects of amantadine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Agitation
  • anxiety
  • difficulty concentrating
  • headache
  • irritability
  • loss of appetite
  • nausea
  • nervousness
  • nightmares
  • purplish red, net-like, or blotchy spots on the skin
  • trouble with sleeping

Less common

  • Constipation
  • decrease in sexual desire
  • diarrhea
  • drowsiness
  • dryness of the mouth, nose, and throat
  • false sense of well-being
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to amantadine: compounding powder, oral capsule, oral capsule extended release, oral syrup, oral tablet, oral tablet extended release

General

The more commonly reported adverse reactions have included nausea, dizziness/lightheadedness, and insomnia.

Nervous system

Common (1% to 10%): Dizziness/lightheadedness, ataxia, headache, somnolence, dystonia

Uncommon (0.1% to 1%): Weakness, slurred speech, hyperkinesia

Rare (less than 0.1%): Convulsion

Frequency not reported: Falling asleep during activities of daily living, withdrawal-emergent hyperpyrexia (a syndrome resembling neuroleptic malignant syndrome)

Postmarketing reports: Coma, delirium, hypokinesia, involuntary muscle contractions, gait abnormalities, paresthesia, EEG changes, tremor

Psychiatric

Very common (10% or more): Hallucinations (up to 21%)

Common (1% to 10%): Insomnia, depression, anxiety, irritability, hallucinations, confusion, nervousness, abnormal dreams, agitation

Uncommon (0.1% to 1%): Psychosis, euphoria, abnormal thinking, amnesia

Rare (less than 0.1%): Suicide attempt, suicide, suicidal ideation

Postmarketing reports: Stupor, delusions, aggressive behavior, paranoid reaction, manic reaction, pathological gambling, increased libido including hypersexuality, and impulse control symptoms

Gastrointestinal

Very common (10% or more): Dry mouth (up to 16%); constipation (up to 13%)

Common (1% to 10%): Nausea, anorexia, diarrhea, decreased appetite

Uncommon (0.1% to 1%): Vomiting

Postmarketing reports: Dysphagia

Cardiovascular

Very common (10% or more): Peripheral edema (up to 16%), orthostatic hypotension (up to 13%)

Uncommon (0.1% to 1%): Congestive heart failure, hypertension

Postmarketing reports: Cardiac arrest, arrhythmias including malignant arrhythmias, hypotension, and tachycardia

Ocular

Common (1% to 10%): Dry eye, cataract, blurred vision

Uncommon (0.1% to 1%): Visual disturbance, punctate subeithelial or other corneal opacity, corneal edema, decreased visual acuity, sensitivity to light, optic nerve palsy

Rare (less than 0.1%): Oculogyric episodes

Postmarketing reports: Keratitis, mydriasis

Other

Very common (10% or more): Fall (up to 13%)

Common (1% to 10%): Fatigue, contusions

Frequency not reported: Death

Postmarketing reports: Fever

Deaths have been reported from overdose with the lowest reported acute lethal dose as 1 gram. Drug overdose has resulted in cardiac, respiratory, renal, or CNS toxicity. Deaths have been reported in patients with renal impairment and attributed to drug accumulation.

Respiratory

Common (1% to 10%): Dry nose, cough

Uncommon (0.1% to 1%): Dyspnea

Postmarketing reports: Acute respiratory failure, pulmonary edema, tachypnea

Hematologic

Rare (less than 0.1%): Leukopenia, neutropenia

Postmarketing reports: Leukocytosis, agranulocytosis

Dermatologic

Common (1% to 10%): Livedo reticularis, pigmentation disorder

Uncommon (0.1% to 1%): Skin rash

Rare (less than 0.1%): Eczematoid dermatitis

Postmarketing reports: Pruritus, diaphoresis

Hypersensitivity

Postmarketing reports: Allergic reactions including anaphylactic reactions

Genitourinary

Common (1% to 10%): Urinary tract infection, benign prostatic hyperplasia

Uncommon (0.1% to 1%): Urinary retention, decreased libido

Renal

Postmarketing reports: Elevated: CPK, BUN, serum creatinine

Hepatic

Rare (less than 0.1%): Reversible liver enzyme elevations

Postmarketing reports: Elevated: alkaline phosphatase, LDH, bilirubin, GGT, SGOT, and SGPT

Musculoskeletal

Common (1% to 10%): Joint swelling, muscle spasms

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Osmolex Er