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Generic Name: hyaluronan (HYE al URE oh nan)
Brand Names: Hymovis, Monovisc, Orthovisc
Orthovisc is injected into the knee joints for the treatment of pain associated with osteoarthritis. Learn about side effects, interactions and indications.
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Drug Information:
Orthovisc (hyaluronan) is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints. Orthovisc is used to treat knee pain caused by osteoarthritis. Orthovisc is usually given after other arthritis medications have been tried without success. You should not receive Orthovisc if are allergic to hyaluronate formulations or gram positive bacterial proteins, or have an infection in your knee or in the skin around your knee. You should not be treated with Orthovisc if you are allergic to hyaluronan, or if you have: Learn more

Orthovisc Side Effects

Orthovisc Side Effects

Note: This document contains side effect information about hyaluronan. Some of the dosage forms listed on this page may not apply to the brand name Orthovisc.

In Summary

Common side effects of Orthovisc include: arthralgia and headache. Other side effects include: back pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hyaluronan: intra-articular gel, intra-articular solution


You should not receive hyaluronan if you have a bleeding disorder, certain allergies, or an infection in your knee or in the skin around your knee.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • bleeding;

  • increased knee pain; or

  • signs of infection (warmth, swelling, redness) around your knee.

Common side effects may include:

  • joint pain, stiffness, or swelling;

  • itching, numbness, or tingling;

  • headache, dizziness;

  • back pain;

  • swelling, pain, redness, or mild discomfort where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hyaluronan: intra-articular gel, intra-articular solution


Uncommon (0.1% to 1%): Injection site erythema, injection site edema


Very common (10% or more): Arthralgia (13%)

Common (1% to 10%): Arthritis, back pain

Uncommon (0.1% to 1%): Arthropathy, joint disorder, joint effusion, joint stiffness, joint swelling, aggravated osteoarthritis, localized osteoarthritis, knee arthroplasty


Uncommon (0.1% to 1%): Baker's cyst, bursitis

Nervous system

Very common (10% or more): Headache (12%)


Uncommon (0.1% to 1%): Erythema, edema

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Orthovisc