Note: This document contains side effect information about irinotecan liposomal. Some of the dosage forms listed on this page may not apply to the brand name Onivyde.
Common side effects of Onivyde include: fever. See below for a comprehensive list of adverse effects.
Applies to irinotecan liposomal: intravenous solution
Intravenous route (Solution)
Fatal neutropenic sepsis has been reported with irinotecan liposome therapy. Life-threatening neutropenia, life-threatening neutropenic fever or sepsis, and severe diarrhea has been reported with irinotecan liposome therapy in combination with fluorouracil and leucovorin. Monitor blood cell counts periodically. Withhold treatment for absolute neutrophil count below 1500/mm(3), neutropenic fever. Severe diarrhea has been reported. Withhold treatment for grade 2 or higher diarrhea. Administer atropine for early diarrhea and administer loperamide for late diarrhea. Do not administer to patients with bowel obstruction.
Along with its needed effects, irinotecan liposomal (the active ingredient contained in Onivyde) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking irinotecan liposomal:
Incidence not known
Some side effects of irinotecan liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to irinotecan liposomal: intravenous dispersion
Very common (10% or more): Diarrhea (70%), nausea (61%), vomiting (54%), abdominal pain (34%), constipation (18%), stomatitis, mucosal inflammation
Common (1% to 10%): Gastroenteritis, oral candidiasis, colitis, hemorrhoids
Uncommon (0.1% to 1%): Esophagitis, proctitis
Very common (10% or more): Alopecia (22%)
Uncommon (0.1% to 1%): Rash maculopapular, nail discoloration
Very common (10% or more): Anemia (33%), neutropenia (15%), leukopenia, thrombocytopenia
Common (1% to 10%): Lymphopenia, febrile neutropenia
Uncommon (0.1% to 1%): Biliary sepsis
Common (1% to 10%): Hypoalbuminemia, increased bilirubin, increased alanine aminotransferase, increased aspartate aminotransferase, increased international normalized ratio
Common (1% to 10%): Infusion related reaction
Very common (10% or more): Decreased appetite (49%), weight loss (20%), hypokalemia, hypomagnesemia, dehydration
Common (1% to 10%): Hypoglycemia, hyponatremia, hypophosphatemia, dehydration
Very common (10% or more): Dizziness (12%)
Common (1% to 10%): Cholinergic syndrome, dysgeusia
Very common (10% or more): Fatigue (37%), asthenia (24%), pyrexia (20%), enema peripheral (19%)
Common (1% to 10%): Acute renal failure
Common (1% to 10%): Septic shock, sepsis
Common (1% to 10%): Back pain
Common (1% to 10%): Insomnia
Common (1% to 10%): Pneumonia, pulmonary embolism, embolism, dyspnea, dysphonia
Common (1% to 10%): Hypotension, deep vein thrombosis
Uncommon (0.1% to 1%): Thrombosis
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Onivyde