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Omeclamox-pak

Generic Name: amoxicillin, clarithromycin, and omeprazole (a MOX i SIL in, kla RITH roe MYE sin, oh MEP ra zole)
Brand Name: Omeclamox-Pak
Physician reviewed Omeclamox-Pak patient information - includes Omeclamox-Pak description, dosage and directions.
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Drug Information:
Amoxicillin is a penicillin antibiotic. Clarithromycin is a macrolide antibiotic. These antibiotics fight bacteria in the body. Omeprazole decreases the amount of acid produced in the stomach. Omeclamox-Pak is a combination medicine used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori). Omeclamox-Pak may also be used for purposes not listed in this medication guide. You should not take Omeclamox-Pak if you've ever had a severe allergic reaction to certain antibiotics. Learn more

Omeclamox-pak Side Effects

Omeclamox-Pak Side Effects

Note: This document contains side effect information about amoxicillin / clarithromycin / omeprazole. Some of the dosage forms listed on this page may not apply to the brand name Omeclamox-Pak.

For the Consumer

Applies to amoxicillin / clarithromycin / omeprazole: oral capsule, oral capsule delayed release, oral tablet

Along with its needed effects, amoxicillin/clarithromycin/omeprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / clarithromycin / omeprazole:

Incidence not known

  • Abdominal or stomach tenderness, cramps, or pain
  • blistering, peeling, or loosening of the skin
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever or chills
  • hives or welts, itching, or skin rash
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or weakness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • redness of the skin
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the body, feet, and ankles
  • tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain
  • watery and severe diarrhea, which may also be bloody

Some side effects of amoxicillin / clarithromycin / omeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • headache

For Healthcare Professionals

Applies to amoxicillin / clarithromycin / omeprazole: oral kit

General

The most commonly reported side effects included diarrhea, taste perversion, and headache.

Clarithromycin: The most commonly reported side effects included diarrhea, nausea, and abnormal taste.

Omeprazole: The most commonly reported side effects included headache, abdominal pain, and nausea.

Gastrointestinal

Very common (10% or more): Diarrhea (up to 14%), taste perversion (up to 10%)

Frequency not reported: Clostridium difficile-associated diarrhea

Amoxicillin:

Postmarketing reports: Diarrhea, hemorrhagic/Clostridium difficile-associated colitis, nausea, tooth discoloration, vomiting

Clarithromycin:

Common (1% to 10%): Abdominal pain/discomfort, diarrhea, dyspepsia, nausea

Postmarketing reports: Glossitis, oral moniliasis, pancreatitis, stomatitis, tooth/tongue discoloration, vomiting

Omeprazole:

Common (1% to 10%): Abdominal pain, acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting

Postmarketing reports: Abdominal swelling, dry mouth, esophageal candidiasis, fecal discoloration, gastric fundic gland polyps, irritable colon, mucosal atrophy of the tongue, pancreatitis/fatal pancreatitis, stomatitis

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Myasthenia gravis

Amoxicillin:

Postmarketing reports: Dizziness, reversible hyperactivity

Clarithromycin:

Common (1% to 10%): Abnormal taste, headache

Postmarketing reports: Altered sense of smell, convulsions, dizziness, taste perversion/loss, tremor, vertigo

Omeprazole:

Common (1% to 10%): Dizziness, headache

Postmarketing reports: Hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo

Hypersensitivity

Postmarketing reports: Hypersensitivity

Clarithromycin:

Postmarketing reports: Allergic reactions, anaphylaxis

Omeprazole:

Postmarketing reports: Anaphylactic shock, anaphylaxis, angioedema, hypersensitivity reactions

Metabolic

Amoxicillin:

Postmarketing reports: Elevated alkaline phosphatase/lactate dehydrogenase

Clarithromycin:

Very rare (less than 0.01%): Anorexia

Postmarketing reports: Hypoglycemia

Omeprazole:

Postmarketing reports: Anorexia, hypoglycemia, hyponatremia, weight gain

Dermatologic

Amoxicillin:

Postmarketing reports: Acute generalized exanthematous pustulosis, erythema multiforme, erythematous maculopapular rashes, exfoliative dermatitis, hypersensitivity vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Clarithromycin:

Postmarketing reports: Mild skin eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Omeprazole:

Common (1% to 10%): Rash

Postmarketing reports: Alopecia, dry skin, erythema hyperhidrosis, multiforme, petechia, photosensitivity, severe generalized skin reactions, skin inflammation pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis/fatal toxic epidermal necrolysis, urticaria

Hepatic

Amoxicillin:

Postmarketing reports: Acute cytolytic hepatitis, AST/ALT/GGT/total bilirubin elevation, cholestatic jaundice, hepatic dysfunction, hepatic cholestasis

Clarithromycin:

Postmarketing reports: Cholestatic/hepatocellular hepatitis with/without jaundice, hepatic dysfunction, haptic failure with fatal outcome, increased liver enzymes

Omeprazole:

Postmarketing reports: Cholestatic disease, hepatic failure/fatal hepatic failure, hepatocellular disease, jaundice, liver disease, liver necrosis/fatal liver necrosis, liver function test elevations (e.g., AST, ALT, bilirubin, GGT, alkaline phosphatase), mixed hepatitis

Hematologic

Amoxicillin:

Postmarketing reports: Agranulocytosis, anemia, decreased white blood cells, eosinophilia, hemolytic anemia, increased prothrombin time, leukopenia, thrombocytopenia, thrombocytopenic purpura

Clarithromycin:

Postmarketing reports: Leukopenia, neutropenia, thrombocytopenia

Omeprazole:

Postmarketing reports: Agranulocytosis/fatal agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, purpura, thrombocytopenia

Psychiatric

Amoxicillin:

Postmarketing reports: Agitation, anxiety, behavioral changes, confusion, insomnia

Clarithromycin:

Postmarketing reports: Anxiety, behavioral changes, confusional state, depersonalization, disorientation, hallucinations, insomnia, manic behavior, nightmares, psychosis

Omeprazole:

Postmarketing reports: Aggression, agitation, anxiety, apathy, confusion, depression, dream abnormalities, hallucination, insomnia, nervousness, psychiatric and sleep disturbances

Renal

Amoxicillin:

Postmarketing reports: Elevated blood urea nitrogen (BUN)/serum creatinine

Clarithromycin:

Postmarketing reports: Interstitial nephritis

Omeprazole:

Postmarketing reports: Glycosuria, increased serum creatinine, interstitial nephritis

Other

Clarithromycin:

Postmarketing reports: Hearing loss, tinnitus

Omeprazole:

Common (1% to 10%): Asthenia

Postmarketing reports: Fatigue, fever, malaise, pain, tinnitus

Cardiovascular

Clarithromycin:

Postmarketing reports: QT prolongation, torsade de pointes, ventricular arrhythmia/tachycardia

Omeprazole:

Postmarketing reports: Angina, blood pressure elevation, bradycardia, chest pain palpitations, peripheral edema, tachycardia

Genitourinary

Amoxicillin:

Postmarketing reports: Crystalluria

Omeprazole:

Postmarketing reports: Hematuria, microscopic pyuria, proteinuria, testicular pain, urinary frequency, urinary tract infection

Respiratory

Omeprazole:

Common (1% to 10%): Cough, Upper respiratory tract infection

Postmarketing reports: Bronchospasm, epistaxis, pharyngeal pain

Musculoskeletal

Omeprazole:

Common (1% to 10%): Back pain

Postmarketing reports: Joint pain, leg pain, muscle cramps/weakness, myalgia

Ocular

Omeprazole:

Postmarketing reports: Anterior ischemic optic neuropathy, blurred vision, double vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis

Oncologic

Omeprazole:

Postmarketing reports: Gastroduodenal carcinoma

Endocrine

Omeprazole:

Postmarketing reports: Gynecomastia

Immunologic

Amoxicillin:

Frequency not reported: Serum sickness-like reaction

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Omeclamox-pak