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Generic Name: sonidegib (SOE ni DEG ib)
Brand Names: Odomzo
Odomzo (sonidegib) is used to treat locally advanced basal cell carcinoma. Includes Odomzo side effects, interactions and indications.
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Drug Information:
Odomzo (sonidegib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Odomzo is used to treat basal cell carcinoma (a type of skin cancer). Odomzo is usually given when surgery or radiation cannot be used, or have been used without success. Odomzo can cause severe birth defects or stillbirth if the mother or father is taking this medicine at the time of conception or during pregnancy. Both men and women using this medicine should use effective birth control to prevent pregnancy. Learn more

Odomzo Side Effects

Odomzo Side Effects

Note: This document contains side effect information about sonidegib. Some of the dosage forms listed on this page may not apply to the brand name Odomzo.

In Summary

Common side effects of Odomzo include: muscle spasm, musculoskeletal pain, and myalgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to sonidegib: oral capsule


Oral route (Capsule)

Use of sonidegib during pregnancy can cause embryofetal death or severe birth defects. Verify pregnancy status prior to initiating treatment and advise females of reproductive potential to use adequate contraception during treatment and for at least 20 months after discontinuation. Male patients with a female partner of reproductive potential must be advised to use adequate contraception during treatment for at least 8 months after discontinuation.

Along with its needed effects, sonidegib (the active ingredient contained in Odomzo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sonidegib:

More common

  • Difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • muscle spasms
  • swollen joints


  • Dark-colored urine
  • fever
  • muscle stiffness
  • unusual tiredness or weakness

Some side effects of sonidegib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • change in taste
  • decreased appetite
  • decreased weight
  • diarrhea
  • hair loss or thinning of the hair
  • headache
  • itching skin
  • loss of taste
  • nausea
  • vomiting

For Healthcare Professionals

Applies to sonidegib: oral capsule


Very common (10% or more): Increased serum creatinine (92%), increased serum creatinine kinase (61%), muscle spasms (54%), musculoskeletal pain (32%), myalgia (19%)

Uncommon (0.1% to 1%): Rhabdomyolysis

75% of patients with increased serum creatinine had levels that remained within normal range.


Very common (10% or more): Alopecia (53%), pruritus (10%)

Common (1% to 10%): Rash, abnormal hair growth


Very common (10% or more): Hyperglycemia (51%), dysgeusia (46%), decreased weight (30%), decreased appetite (23%)

Common (1% to 10%): Dehydration

Nervous system

Very common (10% or more): Dysgeusia (46%), headache (15%)


Very common (10% or more): Increased lipase (43%), nausea (39%), diarrhea (32%), abdominal pain (18%), increased amylase (16%), vomiting (11%)

Common (1% to 10%): Dyspepsia, constipation, GI reflux


Very common (10% or more): Fatigue (41%), pain (14%)


Very common (10% or more): Anemia (32%), lymphopenia (28%)


Very common (10% or more): Increased ALT (19%), increased AST (19%)


Frequency not reported: Amenorrhea

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Odomzo