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Generic Name: ocrelizumab (OK re LIZ ue mab)
Brand Names: Ocrevus
Ocrevus (ocrelizumab) is used to treat relapsing and primary progressive forms of multiple sclerosis. Includes Ocrevus side effects, interactions and indications.
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Drug Information:
Ocrevus (ocrelizumab) is a monoclonal antibody that affects the actions of the body's immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. Ocrevus is used to treat multiple sclerosis (relapsing or progressive forms) in adults. Ocrevus may also be used for purposes not listed in this medication guide. Ocrevus may cause unpleasant side effects while the medicine is injected, or up to 24 hours later. Tell your caregivers if you have unpleasant side effects such as dizziness, nausea, skin rash, chest tightness, or trouble breathing within 24 hours after your injection. Learn more

Ocrevus Side Effects

Ocrevus Side Effects

Note: This document contains side effect information about ocrelizumab. Some of the dosage forms listed on this page may not apply to the brand name Ocrevus.

In Summary

Common side effects of Ocrevus include: lower respiratory tract infection, upper respiratory tract infection, cough, and infusion related reaction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ocrelizumab: intravenous solution

Along with its needed effects, ocrelizumab (the active ingredient contained in Ocrevus) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ocrelizumab:

More common

  • Back pain
  • blurred vision
  • body aches or pain
  • chest tightness
  • chills
  • confusion
  • cough
  • difficulty with breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • fever
  • headache
  • hives, itching, or skin rash
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loss of voice
  • nasal congestion
  • nausea and vomiting
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sneezing
  • sore throat
  • sweating
  • trouble breathing
  • unusual tiredness or weakness

Less common

  • Burning or stinging of the skin
  • painful cold sores or blisters on the lips, nose, eyes, or genitals

Incidence not known

  • Convulsions
  • drowsiness

Some side effects of ocrelizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • diarrhea
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • rapid weight gain
  • tingling of the hands or feet
  • trouble concentrating
  • trouble sleeping
  • unusual weight gain or loss

For Healthcare Professionals

Applies to ocrelizumab: intravenous solution


Very common (10% or more): Upper respiratory tract infection (49%), nasopharyngitis (24%), lower respiratory tract infection (10%)

Common (1% to 10%): Bronchitis, cough


Common (1% to 10%): Depression


Uncommon (0.1% to 1%): Breast cancer


Common (1% to 10%): Back pain, pain in extremity


Very common (10% or more): Infusion reactions (40%)


Common (1% to 10%): Herpes virus associated infections

Frequency not reported: Immunogenicity


Very common (10% or more): Neutrophil levels decreased (13%)


Very common (10% or more): Skin infections (14%)


Common (1% to 10%): Conjunctivitis


Common (1% to 10%): Peripheral edema

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ocrevus