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Generic Name: pimavanserin (PIM a VAN ser in )
Brand Names: Nuplazid
Nuplazid (pimavanserin) is an antipsychotic medicine used to treat hallucinations and delusions in patients with Parkinson's disease. Includes Nuplazid side effects, interactions and indications.
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Drug Information:
Nuplazid (pimavanserin) is an antipsychotic medicine that works by changing the actions of chemicals in the brain. Nuplazid is used to treat hallucinations and delusions caused by psychosis that is related to Parkinson's disease. Nuplazid may increase the risk of death in older adults with dementia-related conditions and is not approved for this use. Nuplazid may increase the risk of death in older adults with dementia-related conditions and is not approved for this use. You should not use Nuplazid if you are allergic to pimavanserin. Learn more

Nuplazid Side Effects

Nuplazid Side Effects

Note: This document contains side effect information about pimavanserin. Some of the dosage forms listed on this page may not apply to the brand name Nuplazid.

In Summary

More frequent side effects include: peripheral edema. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pimavanserin: oral capsule, oral tablet


Oral route (Tablet)

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Pimavanserin is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson's disease psychosis.

Along with its needed effects, pimavanserin (the active ingredient contained in Nuplazid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:

Incidence not known

  • Chest pain or discomfort
  • fainting
  • irregular or slow heart rate
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • tightness in the chest
  • trouble breathing

Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • confusion
  • nausea
  • rapid weight gain
  • unusual weight gain or loss

Less common

  • Change in walking and balance
  • clumsiness or unsteadiness
  • difficulty having a bowel movement

Incidence not known

  • Sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to pimavanserin: oral capsule, oral tablet


The most commonly reported side effects are peripheral edema and confusional state.


Common (1% to 10%): Constipation, nausea

Postmarketing reports: Tongue swelling


Common (1% to 10%): Confusional state, hallucinations

Hallucinations included visual, auditory, tactile, and somatic hallucinations.


Common (1% to 10%): Peripheral edema

Frequency not reported: QT interval prolongation

Nervous system

Common (1% to 10%): Gait disturbance


Common (1% to 10%): Fatigue


Common (1% to 10%): Urinary tract infection


Postmarketing reports: Circumoral edema, rash, urticaria


Postmarketing reports: Angioedema


Postmarketing reports: Dyspnea, throat tightness

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Nuplazid