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Nuedexta

Generic Name: dextromethorphan and quinidine (DEX troe me THOR fan and KWIN i deen)
Brand Names: Nuedexta
Nuedexta is used to treat involuntary outbursts of crying or laughing in people with certain neurological disorders. Includes Nuedexta side effects, interactions and indications.
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Drug Information:
Nuedexta contains a combination of dextromethorphan and quinidine. Dextromethorphan affects the signals in the brain that trigger cough reflex and is generally used as a cough suppressant. Quinidine affects the way that the heart beats and is generally used in people with certain heart rhythm disorders. Nuedexta is used for the treatment of pseudobulbar affect (PBA). Nuedexta treats involuntary outbursts of crying or laughing in people with certain neurological disorders, including multiple sclerosis and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease). Learn more

Nuedexta Side Effects

Nuedexta Side Effects

Note: This document contains side effect information about dextromethorphan / quinidine. Some of the dosage forms listed on this page may not apply to the brand name Nuedexta.

For the Consumer

Applies to dextromethorphan/quinidine: oral capsule

Along with its needed effects, dextromethorphan / quinidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dextromethorphan / quinidine:

Less common

  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • chills
  • cough
  • diarrhea
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • rapid weight gain
  • runny nose
  • shivering
  • sore throat
  • sweating
  • tingling of the hands or feet
  • trouble sleeping
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking dextromethorphan / quinidine:

Symptoms of overdose

  • Aggressive and violent behavior
  • agitation
  • blurred vision
  • change in color vision
  • change in consciousness
  • chest pain or discomfort
  • confusion
  • confusion as to time, place, or person
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased awareness or responsiveness
  • depression
  • difficulty seeing at night
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • excitement
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • hallucinations
  • hearing loss
  • holding false beliefs that cannot be changed by fact
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • increased sensitivity of the eyes to sunlight
  • irregular or slow heart rate
  • loss of consciousness
  • overactive reflexes
  • poor coordination
  • restlessness
  • seeing double
  • seizures
  • sensation of spinning
  • severe sleepiness
  • shakiness and unsteady walk
  • shivering
  • shortness of breath
  • sticking out of tongue
  • sweating
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • trouble with breathing, speaking, or swallowing
  • twitching
  • uncontrolled eye movements
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual excitement, nervousness, or restlessness
  • unusual facial expressions

Some side effects of dextromethorphan / quinidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • lack or loss of strength
  • passing gas

For Healthcare Professionals

Applies to dextromethorphan / quinidine: oral capsule

General

The most commonly reported adverse reactions (2% or greater incidence and greater than placebo) that led to treatment discontinuation were muscle spasticity, abdominal pain, asthenia, dizziness, muscle spasms, respiratory failure, and fall.

Gastrointestinal

Very common (10% or more): Diarrhea (13%)

Common (1% to 10%): Abdominal pain, vomiting, flatulence

Dextromethorphan:

Postmarketing reports: Nausea, vomiting, stomach pain

Nervous system

Very common (10% or more): Dizziness (10%)

Dextromethorphan:

Postmarketing reports: Drowsiness, dizziness, nervousness, restlessness

Quinidine:

Postmarketing reports: Convulsions, apprehension, ataxia, acute psychotic reactions (rare)

Cardiovascular

Frequency not reported: QTc prolongation

Musculoskeletal

Common (1% to 10%): Muscle spasticity, muscle spasms

Hepatic

Common (1% to 10%): Increased gamma-glutamyltransferase

Respiratory

Common (1% to 10%): Respiratory failure, cough

Other

Common (1% to 10%): Asthenia, fall, peripheral edema

Quinidine:

Postmarketing reports: Cinchonism

Cinchonism is usually a sign of chronic quinidine toxicity, but it may appear in sensitive patients after a single moderate dose of several hundred milligrams. It is characterized by nausea, vomiting, diarrhea, tinnitus headache, hearing loss, vertigo, blurred vision, diplopia, photophobia, confusion, and delirium.

Immunologic

Common (1% to 10%): Influenza

Genitourinary

Common (1% to 10%): Urinary tract infection

Ocular

Quinidine:

Postmarketing reports: Mydriasis, disturbed color perception, night blindness, scotomata, optic neuritis, visual field loss, photosensitivity, keratopathy

Dermatologic

Quinidine:

Postmarketing reports: Skin pigmentation abnormalities

Psychiatric

Quinidine:

Postmarketing reports: Depression

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Nuedexta