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Generic Name: romiplostim (ROM i PLOS tim)
Brand Names: Nplate
Nplate is used to prevent bleeding episodes in people with chronic immune thrombocytopenic purpura (ITP). Learn about side effects, interactions and indications.
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Drug Information:
Nplate (romiplostim) is a man-made form of a protein that increases production of platelets (blood-clotting cells) in your body. Nplate is used to prevent bleeding episodes in people with chronic immune thrombocytopenic purpura (ITP), a bleeding condition caused by a lack of platelets in the blood. Nplate is for use in adults and children who are at least 1 year old. Nplate is not a cure for ITP and it will not make your platelet counts normal if you have this condition. It is usually given after other treatments have failed. Learn more

Nplate Side Effects

Nplate Side Effects

Note: This document contains side effect information about romiplostim. Some of the dosage forms listed on this page may not apply to the brand name Nplate.

In Summary

Common side effects of Nplate include: abdominal pain, dizziness, insomnia, limb pain, and myalgia. Other side effects include: dyspepsia, paresthesia, and shoulder pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to romiplostim: subcutaneous powder for solution

Along with its needed effects, romiplostim (the active ingredient contained in Nplate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking romiplostim:


  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficulty with breathing
  • pain in the chest, groin, or legs, especially the calves
  • pinpoint red spots on the skin
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • unusual bleeding or bruising
  • vision changes

Some side effects of romiplostim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • difficulty with moving
  • dizziness
  • headache
  • heartburn
  • indigestion
  • muscle aching or cramping
  • muscle pains or stiffness
  • pain in the arms or legs
  • pain in the joints
  • pain in the shoulder
  • stomach discomfort, upset, or pain
  • swollen joints
  • trouble sleeping

For Healthcare Professionals

Applies to romiplostim: subcutaneous powder for injection


The most serious adverse reactions were increased bone marrow reticulin, thrombotic/thromboembolic complications, and progression of myelodysplastic syndromes (MDS) to acute myelogenous leukemia (AML).


Very common (10% or more): Grade 2 or higher bleeding event (15%)

Common (1% to 10%): Bone marrow reticulin formation increased 2 grades or more, bone marrow collagen fibrosis increased to grade 4, grade 4 bone marrow collagen fibrosis, bone marrow disorder, thrombocytopenia, anemia, thrombocytosis, bone marrow reticulin deposition, anemia, reticulin increased, serious bleeding event

Uncommon (0.1% to 1%): Aplastic anemia, bone marrow failure, leukocytosis, splenomegaly, thrombocythemia, platelet count increased, platelet count abnormal, blood lactate dehydrogenase increased

Frequency not reported: Marrow fibrosis with collagen

Serious bleeding events included any event that was fatal, life-threatening, required hospitalization or prolongation of hospitalization, caused persistent or significant disability/incapacity, congenital anomaly/birth defect, and any other significant hazard.


Common (1% to 10%): Palpitations, flushing, hematoma, hypertension, peripheral ischemia, peripheral embolism

Uncommon (0.1% to 1%): Myocardial infarction, heart rate increased, deep vein thrombosis, hypotension, phlebitis, thrombophlebitis superficial, thrombosis, erythromelalgia, blood pressure increased

Frequency not reported: Congestive heart failure


Common (1% to 10%): B-cell lymphoma

Uncommon (0.1% to 1%): Multiple myeloma, myelofibrosis

Frequency not reported: Progression of myelodysplastic syndromes (MDS) to acute myelogenous leukemia (AML), blast cell counts transiently increased

Nervous system

Very common (10% or more): Headache (up to 36.2%), dizziness (up to 17%)

Common (1% to 10%): Paresthesia, migraine

Uncommon (0.1% to 1%): Clonus, dysgeusia, hypoesthesia, hypogeusia, neuropathy peripheral, transverse sinus thrombosis, vertigo


Very common (10% or more): Upper respiratory tract infection (up to 31%), nasopharyngitis (up to 26.2%), oropharyngeal pain (up to 25%), epistaxis (22.6%), cough (up to 17.3%)

Common (1% to 10%): Pulmonary embolism, sinusitis, bronchitis, dyspnea, nasal congestion, rhinorrhea

Uncommon (0.1% to 1%): Dry throat, painful respiration

Frequency not reported: Upper respiratory tract infection, pneumonia


Very common (10% or more): Arthralgia (up to 26%), back pain (up to 15.8%), pain in extremity (up to 15.6%), myalgia (up to 14%)

Common (1% to 10%): Shoulder pain, muscle spasms, bone pain, musculoskeletal pain

Uncommon (0.1% to 1%): Muscle tightness, muscle weakness, muscle twitching


Very common (10% or more): Contusion (up to 41%), pyrexia (up to 24%), fatigue (up to 23.3%)

Common (1% to 10%): Influenza-like illness, pain, asthenia, chills, injection site reaction, chest pain, peripheral swelling

Uncommon (0.1% to 1%): Injection site hemorrhage, malaise, feeling hot, feeling jittery, body temperature increased


Very common (10% or more): Diarrhea (up to 20%), nausea (up to 19.4%), upper abdominal pain (14%), abdominal pain (up to 11%), vomiting (up to 10.5%)

Common (1% to 10%): Dyspepsia, gastroenteritis, constipation, gingival bleeding, mouth hemorrhage, upper abdominal pain, toothache

Uncommon (0.1% to 1%): Rectal hemorrhage, breath odor, dysphagia, gastroesophageal reflux disease, hematochezia, stomach discomfort, stomatitis, tooth discoloration


Very common (10% or more): Petechiae (18.6%), rash (up to 15%)

Common (1% to 10%): Angioedema, pruritus, ecchymosis, purpura, urticaria

Uncommon (0.1% to 1%): Alopecia, photosensitivity reaction, acne, dermatitis contact, dry skin, eczema, erythema, exfoliative rash, hair growth abnormal, prurigo, rash papular, rash pruritic, skin nodule, skin odor abnormal, face edema


Very common (10% or more): Insomnia (up to 16%)

Common (1% to 10%): Anxiety

Uncommon (0.1% to 1%): Depression, abnormal dreams, irritability


Very common (10% or more): Peripheral edema (up to 12.5%)

Common (1% to 10%): Hypokalemia

Uncommon (0.1% to 1%): Alcohol intolerance, anorexia, appetite decreased, dehydration, gout, weight decreased, weight increased


Very common (10% or more): Antibodies to this drug (up to 16%)

Common (1% to 10%): Preexisting antibodies to this drug, influenza, ear infection

Uncommon (0.1% to 1%): Localized infection, neutralizing antibodies

Frequency not reported: Hypersensitivity


Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Protein urine present, vaginal hemorrhage


Uncommon (0.1% to 1%): Conjunctival hemorrhage, accommodation disorder, blindness, eye disorder, eye pruritus, lacrimation increased, papilledema, visual disturbances


Uncommon (0.1% to 1%): Portal vein thrombosis, transaminase increased

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Nplate