Please wait...


Generic Name: neratinib (ne RA ti nib)
Brand Names: Nerlynx
Nerlynx (neratinib) is used for the extended adjuvant treatment of early-stage, HER2-positive breast cancer. Includes Nerlynx side effects, interactions and indications.
  • Prescription Settings

Prices and coupons of Nerlynx

Current Location: 20149 (Ashburn)
Change Location?

Enter your zip code

Please wait while the prices are loaded...

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
Nerlynx (neratinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Nerlynx is used to treat a certain type of early-stage breast cancer. It is used for this condition only if your tumor tests positive for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells. Nerlynx is usually given after you have been treated with another medicine called trastuzumab (Herceptin). Nerlynx can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may be given anti-diarrhea medications for the first 2 months of treatment with Nerlynx. Learn more

Nerlynx Side Effects

Nerlynx Side Effects

Note: This document contains side effect information about neratinib. Some of the dosage forms listed on this page may not apply to the brand name Nerlynx.

For the Consumer

Applies to neratinib: oral tablet

Along with its needed effects, neratinib (the active ingredient contained in Nerlynx) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking neratinib:

More common

  • Diarrhea

Less common

  • Confusion
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • increase in heart rate
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • thirst
  • unusual tiredness or weakness
  • wrinkled skin


  • Bloody urine
  • increased blood pressure
  • increased thirst
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loss of appetite
  • lower back or side pain
  • nausea
  • raised, firm, bright red patches of skin on the arm or leg
  • stomach pain
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • vomiting
  • weight gain

Some side effects of neratinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • bladder pain
  • bloody nose
  • bloody or cloudy urine
  • decreased appetite
  • decreased weight
  • difficult, burning, or painful urination
  • discoloration of the fingernails or toenails
  • dry skin
  • frequent urge to urinate
  • heartburn
  • indigestion
  • muscle spasms
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth

Less common

  • Deep cracks, grooves, or lines in the skin
  • dry mouth

For Healthcare Professionals

Applies to neratinib: oral tablet


The most common adverse reactions (more than 5%) were diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, increased AST or ALT, nail disorder, dry skin, abdominal distention, decreased weight, and urinary tract infection.


Very common (10% or more): Diarrhea (95%), nausea (43%), abdominal pain (36%), vomiting (26%), stomatitis (14%), dyspepsia (10%)

Common (1% to 10%): Abdominal distention, dry mouth


Very common (10% or more): Fatigue (27%)


Very common (10% or more): Rash (18%)

Common (1% to 10%): Nail disorder, rash, skin fissures


Very common (10% or more): Decreased appetite (12%)

Common (1% to 10%): Decreased weight, dehydration


Very common (10% or more): Muscle spasms (11%)


Common (1% to 10%): Urinary tract infection


Common (1% to 10%): Increased ALT, increased AST


Common (1% to 10%): Epistaxis


Frequency not reported: Hypotension


Frequency not reported: Renal failure

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Nerlynx