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Navelbine

Generic Name: vinorelbine (vin OR el been)
Brand Name: Navelbine
Physician reviewed Navelbine patient information - includes Navelbine description, dosage and directions.
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Drug Information:
Navelbine is used to treat non-small cell lung cancer. Navelbine is sometimes used in combination with other cancer medications. Navelbine may also be used for other purposes not listed in this medication guide. Navelbine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, tiredness, cough, skin sores, bruising, pale skin, unusual bleeding, or trouble breathing. You should not be treated with Navelbine if you are allergic to it, or if you have severely low white blood cell counts. Learn more

Navelbine Side Effects

Navelbine Side Effects

Note: This document contains side effect information about vinorelbine. Some of the dosage forms listed on this page may not apply to the brand name Navelbine.

For the Consumer

Applies to vinorelbine: intravenous solution

Warning

Intravenous route (Solution)

Myelosuppression: Severe myelosuppression resulting in serious infection, septic shock, hospitalization and death may occur. Decrease the dose or withhold vinorelbine in accord with recommended dose modifications.

Along with its needed effects, vinorelbine (the active ingredient contained in Navelbine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vinorelbine:

More common

  • Cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • lower back or side pain, accompanied by fever or chills
  • painful or difficult urination, accompanied by fever or chills
  • redness, increased warmth, pain, or discoloration of vein at place of injection
  • sore throat, accompanied by fever or chills

Less common

  • Chest pain
  • shortness of breath
  • sores in mouth and on lips

Rare

  • Black, tarry stools
  • bloating
  • blood in urine or stools
  • chills
  • darkened urine
  • fast heartbeat
  • fever
  • indigestion
  • loss of appetite
  • nausea
  • painful urination
  • pains in stomach
  • pinpoint red spots on skin
  • skin rash
  • unusual bleeding or bruising
  • vomiting
  • yellow eyes or skin

Check with your doctor as soon as possible if any of the following side effects occur while taking vinorelbine:

More common

  • Loss of strength and energy
  • unusual tiredness or weakness

Less common

  • Numbness or tingling in fingers and toes

Symptoms of overdose

  • Chest pain
  • cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • heartburn
  • lower back or side pain, accompanied by fever or chills
  • mild abdominal pain and constipation
  • numbness or tingling in fingers and toes
  • painful or difficult urination, accompanied by fever or chills
  • sore throat, accompanied by fever or chills
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Some side effects of vinorelbine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • loss of appetite
  • nausea and vomiting

Less common

  • Diarrhea
  • jaw pain
  • joint or muscle pain

For Healthcare Professionals

Applies to vinorelbine: intravenous solution

Hematologic

Very common (10% or more): Neutropenia (89%), anemia (89%), leukopenia (88%), thrombocytopenia (29%)

Frequency not reported: Febrile neutropenia

Hepatic

Very common (10% or more): AST increased (67%), bilirubin increased (13%)

Gastrointestinal

Very common (10% or more): Nausea (44%), constipation (35%), vomiting (20%), diarrhea (17%), stomatitis (15%), abdominal pain

Common (1% to 10%): Esophagitis

Rare (less than 0.1%): Paralytic ileus, pancreatitis

Frequency not reported: GI bleeding

Local

Very common (10% or more): Injection site reactions (e.g., erythema, burning sensation, venous discoloration, local phlebitis)

Rare (less than 0.1%): Local necrosis

Frequency not reported: Neutropenic septicemia

Nervous system

Very common (10% or more): Peripheral neuropathy (25%), neurological alterations (e.g., loss of deep tendon reflexes)

Uncommon (0.1% to 1%): Severe paresthesia with sensory and motor symptoms

Dermatologic

Very common (10% or more): Alopecia (12%)

Rare (less than 0.1%): Generalized skin reactions

Frequency not reported: Erythema of hands and feet

Postmarketing reports: Pruritus, urticaria

Cardiovascular

Common (1% to 10%): Phlebitis, chest pain

Uncommon (0.1% to 1%): Hypotension, hypertension, flushing, peripheral coldness

Rare (0.01% to 0.1%): Ischemic heart disease (e.g., angina pectoris, myocardial infarction), severe hypotension, cardiovascular collapse

Very rare (less than 0.01%): Tachycardia, palpitations, altered heart rhythm

Frequency not reported: Myocardial infarction

Respiratory

Common (1% to 10%): Dyspnea, cough

Uncommon (0.1% to 1%): Bronchospasm

Rare (less than 0.1%): Interstitial lung disease

Postmarketing reports: Pneumonia, pulmonary edema

Musculoskeletal

Very common (10% or more): Lower limb weakness

Common (1% to 10%): Arthralgia, myalgia, pain in jaw

Rare (less than 0.1%): Severe hyponatremia

Genitourinary

Common (1% to 10%): Dysuria

Metabolic

Very common (10% or more): Stomatitis (15%), anorexia, weight loss

Common (1% to 10%): Weight gain

Frequency not reported: Anorexia

Hypersensitivity

Frequency not reported: Systemic allergic reactions (e.g., anaphylaxis, anaphylactic shock, anaphylactoid reaction)

Postmarketing reports: Angioedema

Immunologic

Common (1% to 10%): Common (1% to 10%): Bacterial, viral, or fungal infections (e.g., respiratory tract, urinary tract, GI tract)

Uncommon (0.1% to 1%): Severe sepsis, septicemia

Very rare (less than 0.01%): Complicated septicemia (sometimes fatal)

Ocular

Common (1% to 10%): Visual disorder

Psychiatric

Common (1% to 10%): Insomnia

Other

Very common (10% or more): Asthenia (36%), ototoxicity (10%)

Common (1% to 10%): Fatigue, fever, pain at different sites (e.g., chest pain, pain at the site of the tumor, headache, dizziness, taste disorder

Uncommon (0.1% to 1%): Ataxia

Endocrine

Frequency not reported: Syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Navelbine