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Generic Name: Primidone (PRI mi done)
Brand Name: Mysoline
Easy-to-read patient leaflet for Mysoline. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Mysoline (primidone). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Mysoline (primidone) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Mysoline (primidone) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Mysoline Side Effects

Mysoline Side Effects

Note: This document contains side effect information about primidone. Some of the dosage forms listed on this page may not apply to the brand name Mysoline.

For the Consumer

Applies to primidone: oral tablet

Along with its needed effects, primidone (the active ingredient contained in Mysoline) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking primidone:

More common

  • Shakiness and unsteady walk
  • unsteadiness, trembling, or other problems with muscle control or coordination

Less common

  • Unusual excitement or restlessness (especially in children and in the elderly)


  • Chills
  • cough or hoarseness
  • fainting spells
  • fever and sore throat
  • fever with or without chills
  • general feeling of tiredness or weakness
  • irregular heartbeat
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • skin rash
  • sores, ulcers, or white spots on the lips or in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking primidone:

Symptoms of overdose

  • Confusion
  • continuous, uncontrolled rolling eye movements
  • double vision
  • troubled breathing

Some side effects of primidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Clumsiness or unsteadiness
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • sensation of spinning

Less common

  • Decreased sexual ability
  • drowsiness
  • loss of appetite
  • mood or mental changes
  • nausea or vomiting

For Healthcare Professionals

Applies to primidone: oral suspension, oral tablet


Uncommon (0.1% to 1%): Allergic reactions (e.g., maculopapular, morbilliform, or scarlatiniform)

Rare (0.01% to 0.1%): Exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, lupus erythematosus


Rare (0.01% to 0.1%): Megaloblastic anemia, blood dyscrasias, granulocytopenia, agranulocytosis, red-cell hypoplasia and aplasia


Rare (0.01% to 0.1%): Arthralgia, osteomalacia, Dupuytren's contracture


Common (1% to 10%): Visual disturbances

Uncommon (0.1% to 1%): Diplopia, nystagmus


Frequency not reported: Anorexia


Uncommon (0.1% to 1%): Hyperirritability, emotional disturbances

Rare (0.01% to 0.1%): Personality changes, psychosis



Uncommon (0.1% to 1%): Sexual impotency


Rare (0.01% to 0.1%): Elevations in hepatic enzymes (e.g., gamma-glutamyl transferase [gamma GT], alkaline phosphatase)

Nervous system

Common (1% to 10%): Drowsiness, listlessness, ataxia, nystagmus, vertigo

Uncommon (0.1% to 1%): Headache, dizziness


Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Vomiting

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Mysoline