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Generic Name: mycophenolic acid (MYE koe phe NOLE ik AS id)
Brand Names: Myfortic
Myfortic (mycophenolic acid) is used to prevent your body from rejecting a kidney transplant. Includes Myfortic side effects, interactions and indications.
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Drug Information:
Myfortic (mycophenolic acid) is an immunosuppressant that weakens your body's immune system. Your body may "reject" an organ transplant when the immune system treats the new organ as an invader and attacks it. An immunosuppressant helps to prevent this rejection. Myfortic is used to prevent your body from rejecting a kidney transplant. Myfortic is usually given with cyclosporine and a steroid medicine. Myfortic may cause your body to overproduce white blood cells. This can lead to cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure. Learn more

Myfortic Side Effects

Myfortic Side Effects

Note: This document contains side effect information about mycophenolic acid. Some of the dosage forms listed on this page may not apply to the brand name Myfortic.

In Summary

Common side effects of Myfortic include: cytomegalovirus disease, urinary tract infection, anemia, constipation, diarrhea, dyspepsia, insomnia, leukopenia, nausea, vomiting, and postoperative pain. Other side effects include: herpes simplex infection, and herpes zoster infection. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to mycophenolic acid: oral tablet enteric coated


Oral route (Tablet, Enteric Coated)

Use during pregnancy is associated with increased risks of pregnancy loss and congenital malformations. Females of reproductive potential must be counseled regarding pregnancy prevention and planning. Increased risk of development of lymphoma and other malignancies, particularly of the skin, due to immunosuppression. Increased susceptibility to bacterial, viral, fungal, and protozoal infections, including opportunistic infections. Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe mycophenolate sodium. Manage patients in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete information requisite for the follow-up of the patient.

Along with its needed effects, mycophenolic acid (the active ingredient contained in Myfortic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mycophenolic acid:

More common

  • Abdominal or stomach pain or cramps
  • black, tarry stools
  • bladder pain
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • blurred vision
  • body aches or pain
  • bone pain
  • burning or stinging of the skin
  • chest pain
  • cloudy urine
  • confusion
  • constipation
  • convulsions
  • cough
  • decrease in the amount of urine
  • decreased frequency or amount of urine
  • depression
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • drowsiness
  • dry mouth
  • ear congestion
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever or chills
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • incoherent speech
  • increase in heart rate
  • increased blood pressure
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of consciousness
  • loss of voice
  • lower back, side, or stomach pain
  • metallic taste
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle spasms or twitching
  • muscle weakness
  • nausea or vomiting
  • nervousness
  • noisy, rattling breathing
  • numbness and tingling around the mouth, fingertips, hands, or feet
  • painful blisters on the trunk of the body
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • pale skin
  • pinpoint red spots on the skin
  • rapid breathing
  • red, tender, or oozing skin at incision
  • runny nose
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sunken eyes
  • sweating
  • swelling
  • swollen glands
  • thirst
  • tightness in the chest
  • tremor
  • trouble breathing at rest or with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness or heaviness of the legs

Some side effects of mycophenolic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • anxiety
  • back pain
  • belching
  • bleeding gums
  • blemishes on the skin
  • bruising
  • diarrhea
  • difficulty moving
  • excess air or gas in the stomach or intestines
  • facial hair growth in females
  • full feeling
  • full or round face, neck, or trunk
  • heartburn
  • increased hair growth, especially on the face
  • increased thirst or urination
  • indigestion
  • irritability
  • irritation in the mouth
  • itching skin
  • loose stools
  • loss of sexual desire or ability
  • menstrual irregularities
  • muscle pains or stiffness
  • pain
  • pain or tenderness around the eyes and cheekbones
  • passing gas
  • pimples
  • redness and swelling of the gums
  • shakiness in the legs, arms, hands, or feet
  • sleeplessness
  • sore mouth or tongue
  • stomach discomfort or upset
  • trouble sleeping
  • upper abdominal or stomach pain
  • white patches in the mouth or on the tongue

For Healthcare Professionals

Applies to mycophenolic acid: oral delayed release tablet


Common (1% to 10%): Acne, pruritus

Uncommon (0.1% to 1%): Alopecia


Very common (10% or more): Hypertension

Common (1% to 10%): Hypotension

Uncommon (0.1% to 1%): Tachycardia, ventricular extrasystoles, lymphocele


Very common (10% or more): Leukopenia

Common (1% to 10%): Anemia, thrombocytopenia

Uncommon (0.1% to 1%): Lymphopenia, neutropenia, lymphadenopathy

Frequency not reported: Pancytopenia, pure red cell aplasia (PRCA), abnormal neutrophil morphology (including the acquired Pelger-Huet anomaly)


Very common (10% or more): Infections (viral, bacterial, fungal)

Uncommon (0.1% to 1%): Wound infection, sepsis, osteomyelitis, influenza like illness

Frequency not reported: Hypogammaglobulinemia


Very common (10% or more): Arthralgia

Common (1% to 10%): Myalgia

Uncommon (0.1% to 1%): Arthritis, back pain, muscle cramps


Uncommon (0.1% to 1%): Conjunctivitis, vision blurred


Very common (10% or more): Hypocalcemia, hypokalemia, hyperuricemia

Common (1% to 10%): Hyperkalemia, hypomagnesemia

Uncommon (0.1% to 1%): Anorexia, hyperlipidemia, diabetes mellitus, hypercholesterolemia, hypophosphatemia, thirst


Very common (10% or more): Anxiety

Uncommon (0.1% to 1%): Abnormal dreams, delusional perception, insomnia


Uncommon (0.1% to 1%): Impotence


Common (1% to 10%): Abnormal liver function tests


Uncommon (0.1% to 1%): Skin papilloma, basal cell carcinoma, Kaposi´s sarcoma, lymphoproliferative disorder, squamous cell carcinoma


Very common (10% or more): Cough, dyspnea, exertional dyspnea

Common (1% to 10%): Upper respiratory tract infection, pneumonia, cough, dyspnea

Uncommon (0.1% to 1%): Interstitial lung disease (including fatal pulmonary fibrosis), pulmonary congestion, wheezing, pulmonary edema


Common (1% to 10%): Asthenia, fatigue, peripheral edema, pyrexia

Uncommon (0.1% to 1%): Lower limb edema, pain, rigors, weakness, contusion

Frequency not reported: Congenital malformations, spontaneous abortion

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Tremor


Common (1% to 10%): Blood creatinine increased

Uncommon (0.1% to 1%): Hematuria, renal tubular necrosis, urethral stricture


Very common (10% or more): Diarrhea

Common (1% to 10%): Abdominal distension, abdominal pain, constipation, dyspepsia, flatulence, gastritis, nausea, vomiting

Uncommon (0.1% to 1%): Abdominal tenderness, GI hemorrhage, eructation, halitosis, ileus, lip ulceration, esophagitis, subileus, tongue discoloration, dry mouth, gastroesophageal reflux disease, gingival hyperplasia, pancreatitis, parotid duct obstruction, peptic ulcer, peritonitis

Frequency not reported: Colitis, CMV gastritis, intestinal perforation, gastric ulcers, duodenal ulcers

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Myfortic