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Generic Name: dronedarone (droe NE da rone)
Brand Names: Multaq
Multaq (dronedarone) is an antiarrhythmic medication used to treat atrial fibrillation and atrial flutter. Learn about side effects, interactions and indications.
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Drug Information:
Multaq (dronedarone) is a heart rhythm medicine that helps maintain normal heartbeats in certain people with life-threatening rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). Multaq helps lower your risk of needing to be hospitalized for a heart rhythm disorder called atrial fibrillation. Multaq is for people who have had this disorder in the past, but now have normal heart rhythm. You should not use Multaq if you have severe liver disease, if you are pregnant or breast-feeding, or if you have ever used amiodarone and then had liver or lung problems. You should not use Multaq if you have a serious heart condition such as very slow heartbeats, "sick sinus syndrome," or "AV block" (unless you have a pacemaker). Learn more

Multaq Side Effects

Multaq Side Effects

Note: This document contains side effect information about dronedarone. Some of the dosage forms listed on this page may not apply to the brand name Multaq.

In Summary

More frequent side effects include: abdominal pain, allergic dermatitis, diarrhea, eczema, nausea, pruritus, and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dronedarone: oral tablet


Oral route (Tablet)

In patients with symptomatic heart failure and recent decompensation requiring hospitalization or NYHA Class IV heart failure, dronedarone hydrochloride doubles the risk of death. Dronedarone hydrochloride is contraindicated in patients with symptomatic heart failure with recent decompensation requiring hospitalization or NYHA Class IV heart failure. In patients with permanent atrial fibrillation, dronedarone hydrochloride doubles the risk of death, stroke, and hospitalization for heart failure. Dronedarone hydrochloride is contraindicated in patients in atrial fibrillation (AF) who will not or cannot be cardioverted into normal sinus rhythm .

Along with its needed effects, dronedarone (the active ingredient contained in Multaq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dronedarone:

Less common

  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness

Incidence not known

  • Abdominal or stomach pain, severe
  • chills
  • cough
  • dark urine
  • fever
  • general feeling of discomfort or illness
  • loss of appetite
  • nausea or vomiting
  • thickening of bronchial secretions
  • unusual tiredness or weakness
  • yellow eyes or skin

Some side effects of dronedarone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • lack or loss of strength

Less common

  • Acid or sour stomach
  • belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, or scaly skin
  • heartburn
  • indigestion
  • itching skin
  • rash
  • redness or discoloration of the skin
  • skin rash, encrusted, scaly, and oozing
  • skin rash, hives, itching, or redness
  • stomach discomfort, upset, or pain
  • swelling


  • Change in taste
  • increased sensitivity of the skin to sunlight
  • loss of taste
  • severe sunburn

For Healthcare Professionals

Applies to dronedarone: oral tablet


Very common (10% or more): QT prolongation (28%)

Common (1% to 10%): Bradycardia

Very rare (less than 0.01%): New or worsening heart failure, atrial flutter with 1:1 atrioventricular conduction


Frequency not reported: Hypokalemia and hypomagnesemia with potassium-depleting diuretics, serum creatinine increased 10% or more within 5 days after treatment initiation


Common (1% to 10%): Diarrhea, nausea, abdominal pain, vomiting, dyspeptic symptoms

Frequency not reported: Dysgeusia, ageusia


Common (1% to 10%): Rashes (generalized, macular, maculopapular, erythematous), pruritus, eczema, dermatitis, allergic dermatitis

Uncommon (0.1% to 1%): Photosensitivity


Common (1% to 10%): Asthenia, fatigue


Frequency not reported: Liver injury, including acute liver failure requiring transplant, serum hepatic enzymes, serum bilirubin increase


Frequency not reported: Dyspnea, nonproductive cough

Postmarketing reports: Interstitial lung disease including pneumonitis and pulmonary fibrosis


Common (1% to 10%): Urinary tract infection


Postmarketing reports: Vasculitis, including leukocytoclastic vasculitis


Postmarketing reports: Anaphylactic reactions including angioedema


Frequency not reported: Increased serum creatinine

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Multaq