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Mucinex d

Generic Name: guaifenesin and pseudoephedrine (gwye FEN e sin, soo doe e FED rin)
Brand Names: Altarussin PE, Ambifed, Biotuss PE, D-Feda II, Despec-SR, Dynex, ExeFen, Guiatex II SR, Maxifed, Maxifed-G, Medent LD, Medent-LDI, Mucinex D, Nasabid SR, Nasatab LA, Nomuc-PE, Poly-Vent IR, Poly-Vent, Jr., Pseudatex, Pseudo GG, Pseudo GG TR, Pseudo Max, Q-Tussin PE, Respaire-120 SR, Robitussin Severe Congestion, Ru-Tuss Jr., Sudafed Non Drying Sinus, SudaTex-G, Touro LA-LD, Triaminic Softchews Chest Congestion, We Mist II LA, We Mist LA
Mucinex D (guaifenesin and pseudoephedrine) is used to treat nasal and sinus congestion, and to help reduce chest congestion. Includes Mucinex D side effects, interactions and indications.
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Drug Information:
Mucinex D extended release tablets contain a combination of guaifenesin and pseudoephedrine. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Mucinex D tablets are used to treat nasal and sinus congestion. Mucinex D also is used to reduce chest congestion caused by the common cold, infections, or allergies. Learn more

Mucinex d Side Effects

Mucinex D Side Effects

Note: This document contains side effect information about guaifenesin / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Mucinex D.

For the Consumer

Applies to guaifenesin / pseudoephedrine: oral capsule, oral liquid, oral syrup, oral tablet, oral tablet extended release 12 hour

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling nervous and excitable.
  • Not able to sleep.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to guaifenesin/pseudoephedrine: oral capsule, oral capsule extended release, oral liquid, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release


Frequency not reported: Tachycardia, palpitations, other cardiac dysrhythmias, hypertension

Nervous system

Frequency not reported: Headache, dizziness, tremor, excitability


Frequency not reported: Irritability, tolerance and dependence (with prolonged pseudoephedrine administration), anxiety, restlessness, insomnia, hallucinations (particularly in children), paranoid delusions, sleep disturbance


Frequency not reported: Hypersensitivity reactions, cross-sensitivity with other sympathomimetics


Frequency not reported: Difficulty in micturition (including urinary retention)


Frequency not reported: Skin reactions (including rash, sweating), severe skin reactions including acute generalized exanthematous pustulosis (AGEP)


Frequency not reported: Nausea, vomiting, gastrointestinal discomfort, dry mouth


Frequency not reported: Muscular weakness


Frequency not reported: Thirst

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Mucinex D