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Generic Name: naloxegol (nal OX ee gol)
Brand Names: Movantik
Movantik (naloxegol) is used to treat opioid-induced constipation. Includes Movantik side effects, interactions and indications.
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Drug Information:
Movantik (naloxegol) blocks certain effects of opioid medication. An opioid is sometimes called a narcotic. Movantik reduces constipation caused by opioid (narcotic) pain medicine used to treat severe chronic pain. Naloxegol works by treating constipation without reducing the pain-relieving effects of the narcotic. Movantik is used in people who have been taking narcotic pain medicine for at least 4 weeks, to treat chronic pain that is not caused by cancer. You should not use Movantik if you have a blockage in your stomach or intestines. Learn more

Movantik Side Effects

Movantik Side Effects

Note: This document contains side effect information about naloxegol. Some of the dosage forms listed on this page may not apply to the brand name Movantik.

In Summary

Common side effects of Movantik include: abdominal pain. Other side effects include: diarrhea and flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to naloxegol: oral tablet

Along with its needed effects, naloxegol (the active ingredient contained in Movantik) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking naloxegol:

Less common

  • Anxiety
  • chills
  • diarrhea
  • increased sweating
  • irritability
  • stomach pain
  • yawning

Incidence not known

  • Bloody, black or tarry stools
  • heartburn
  • indigestion
  • nausea
  • severe abdominal or stomach pain, cramping, or burning
  • trouble breathing
  • vomiting of material that looks like coffee grounds, severe and continuous

Some side effects of naloxegol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloated
  • excess air or gas in the stomach or bowels
  • full feeling
  • passing of gas

Less common

  • Headache
  • vomiting

For Healthcare Professionals

Applies to naloxegol: oral tablet


The most common adverse reactions include abdominal pain, nausea, diarrhea, headache, vomiting, and flatulence.


Common (1% to 10%): Possible opioid withdrawal (3 or more symptoms on the same day including, but not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning)

Possible opioid withdrawal defined as at least 3 adverse reactions potentially related to opioid withdrawal occurring on the same day and not all related to the gastrointestinal system occurred in less than 1% of patients (5 of 441) receiving the 12.5 mg dose and 3% of patients (14 of 446) receiving the 25 mg dose. Symptoms included, but were not limited to hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning. For patients receiving methadone, higher frequencies of gastrointestinal adverse reactions were observed compared with other opioids.


Very common (10% or more): Abdominal pain (up to 21%)

Common (1% to 10%): Diarrhea, nausea, flatulence, vomiting

Reports of severe abdominal pain and/or diarrhea resulting in hospitalization have occurred. Most cases were reported at the higher dose and within a few days of initiating therapy.


Common (1% to 10%): Hyperhidrosis

Nervous system

Common (1% to 10%): Headache


Common (1% to 10%): Nasopharyngitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Movantik