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Generic Name: Difenoxin and Atropine (dye fen OKS in & A troe peen)
Brand Name: Motofen
Easy-to-read patient leaflet for Motofen. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
For all patients taking Motofen (difenoxin and atropine): Children: This is not a list of all drugs or health problems that interact with Motofen (difenoxin and atropine). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Motofen (difenoxin and atropine) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Learn more

Motofen Side Effects

Motofen Side Effects

Note: This document contains side effect information about atropine / difenoxin. Some of the dosage forms listed on this page may not apply to the brand name Motofen.

For the Consumer

Applies to atropine/difenoxin: oral tablet

Along with its needed effects, atropine/difenoxin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine / difenoxin:

  • Bloating
  • constipation
  • loss of appetite
  • stomach pain (severe) with nausea and vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking atropine / difenoxin:

  • Blurred vision (continuing) or changes in near vision
  • drowsiness (severe)
  • dryness of mouth, nose, and throat (severe)
  • fast heartbeat
  • shortness of breath or troubled breathing (severe)
  • unusual excitement, nervousness, restlessness, or irritability
  • unusual warmth, dryness, and flushing of skin

Some side effects of atropine / difenoxin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Blurred vision
  • confusion
  • difficult urination
  • dizziness or lightheadedness
  • drowsiness
  • dryness of skin and mouth
  • fever
  • headache
  • trouble in sleeping
  • unusual tiredness or weakness

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Increased sweating
  • muscle cramps
  • nausea or vomiting
  • shivering or trembling
  • stomach cramps

For Healthcare Professionals

Applies to atropine / difenoxin: oral tablet


Common (1% to 10%): Vomiting, dry mouth, epigastric distress

Uncommon (0.1% to 1%): Constipation

Nervous system

Common (1% to 10%): Dizziness and light-headedness, drowsiness, headache

Uncommon (0.1% to 1%): Tiredness, nervousness, insomnia, confusion


Frequency not reported: Burning eyes, blurred vision

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Motofen