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Generic Name: Metyrapone (me TEER a pone)
Brand Name: Metopirone
Easy-to-read patient leaflet for Metopirone. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Metopirone (metyrapone). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Metopirone (metyrapone) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Metopirone (metyrapone) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Metopirone Side Effects

Metopirone Side Effects

Note: This document contains side effect information about metyrapone. Some of the dosage forms listed on this page may not apply to the brand name Metopirone.

Applies to metyrapone: oral capsule

Along with its needed effects, metyrapone (the active ingredient contained in Metopirone) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking metyrapone:

Rare (with long-term use)

  • Irregular heartbeat

Check with your doctor as soon as possible if any of the following side effects occur while taking metyrapone:

Less common

  • Skin rash

Rare (usually with long-term use)

  • Enlargement of clitoris
  • muscle cramps or pain
  • sore throat or fever
  • swelling of feet or lower legs
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weight gain (rapid)

Symptoms of overdose

  • Abdominal or stomach pain (severe)
  • confusion
  • decrease in consciousness
  • diarrhea (severe)
  • nausea (severe)
  • nervousness
  • unusual thirst
  • vomiting (severe)
  • weakness (sudden)

Some side effects of metyrapone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dizziness
  • drowsiness
  • headache
  • lightheadedness
  • nausea


  • Confusion or mental slowing
  • excessive hair growth
  • greater-than-normal loss of scalp hair
  • increased sweating
  • loss of appetite
  • upper abdominal or stomach pain
  • vomiting
  • worsening of acne

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Metopirone (metyrapone)

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  • Drug class: adrenal corticosteroid inhibitors

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Professional resources

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Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Metopirone