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Generic Name: methylergonovine (oral and injection) (meth il er GON o veen)
Brand Name: Methergine
Physician reviewed Methergine (oral and injection) (oral and injection) patient information - includes Methergine (oral and injection) description, dosage and directions.
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Drug Information:
Methergine is in a group of drugs called ergot alkaloids. It affects the smooth muscle of a woman's uterus, improving the muscle tone as well as the strength and timing of uterine contractions. Methergine is used just after a baby is born, to help deliver the placenta (also called the "afterbirth"). It is also used to help control bleeding and to improve muscle tone in the uterus after childbirth. Methergine may also be used for purposes not listed in this medication guide. You should not use Methergine during your pregnancy. This medication is to be used only after delivery of your baby. Learn more

Methergine Side Effects

Methergine Side Effects

Note: This document contains side effect information about methylergonovine. Some of the dosage forms listed on this page may not apply to the brand name Methergine.

For the Consumer

Applies to methylergonovine: oral tablet

Other dosage forms:

  • injection solution

Along with its needed effects, methylergonovine (the active ingredient contained in Methergine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methylergonovine:

More common

  • Abdominal pain
  • headache
  • increased blood pressure


  • Blood in the urine
  • change in skin color
  • chest pain or discomfort
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • lightheadedness, dizziness, or fainting
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow or fast heartbeat
  • skin rash
  • sweating
  • vomiting

Incidence not known

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • inability to speak
  • seizures
  • severe or sudden headache
  • slurred speech
  • temporary blindness
  • weakness in the arm or leg on one side of the body, sudden and severe

Some side effects of methylergonovine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Continuous ringing or buzzing or other unexplained noise in the ears
  • cramps in the legs
  • diarrhea
  • foul taste
  • increased sweating
  • nausea
  • stuffy nose

For Healthcare Professionals

Applies to methylergonovine: injectable solution, oral tablet


The most commonly reported adverse reaction is hypertension.


Frequency not reported: Hypertension, hypotension, palpitations, acute myocardial infarction, transient chest pains, arterial spasm (coronary and peripheral), bradycardia, tachycardia

Postmarketing reports: Ventricular fibrillation, ventricular tachycardia, angina pectoris, atrioventricular block

Nervous system

Frequency not reported: Headache, dizziness, seizure

Postmarketing reports: Cerebrovascular accident, paraesthesia


Frequency not reported: Thrombophlebitis


Frequency not reported: Hematuria, abdominal pain associated with uterine contractions


Frequency not reported: Water intoxication


Frequency not reported: Diarrhea, foul taste, nausea, vomiting


Frequency not reported: Dyspnea, nasal congestion


Frequency not reported: Hallucinations


Frequency not reported: Diaphoresis, rash


Frequency not reported: Leg cramps


Frequency not reported: Tinnitus


Frequency not reported: Anaphylaxis (no proven causal relationship)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Methergine