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Generic Name: trametinib (tra ME ti nib)
Brand Names: Mekinist
Mekinist is used to treat metastatic melanoma (skin cancer that has spread to other parts of the body). Learn about side effects, interactions and indications.
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Drug Information:
Mekinist (trametinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Mekinist is used alone or in combination with another medicine called dabrafenib (Tafinlar) to treat certain types of cancer in people who have a "BRAF" gene mutation. Mekinist is for use in treating: melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery; non-small cell lung cancer that has spread to other parts of the body; or Learn more

Mekinist Side Effects

Mekinist Side Effects

Note: This document contains side effect information about trametinib. Some of the dosage forms listed on this page may not apply to the brand name Mekinist.

In Summary

Common side effects of Mekinist include: acneiform eruption, cardiomyopathy, decreased left ventricular ejection fraction, dermatitis, palmar-plantar erythrodysesthesia, skin rash, and erythema of skin. Other side effects include: cardiac failure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trametinib: oral tablet

Along with its needed effects, trametinib (the active ingredient contained in Mekinist) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trametinib:

More common

  • Bleeding from the rectum or bloody stools
  • bleeding gums
  • blemishes on the skin
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody nose
  • blurred vision
  • chest discomfort or pain
  • cracked, dry, or scaly skin
  • coughing up blood
  • decreased urine output
  • diarrhea
  • difficulty with breathing or swallowing
  • dilated neck veins
  • extreme tiredness or weakness
  • fast, slow, irregular, or pounding heartbeat
  • headache
  • increased menstrual flow or vaginal bleeding
  • irregular breathing
  • lightheadedness, dizziness, or fainting
  • nervousness
  • nosebleeds
  • paralysis
  • pimples
  • pounding in the ears
  • prolonged bleeding from cuts
  • rapid weight gain
  • rash
  • red or black, tarry stools
  • red or dark brown urine
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • tightness in the chest
  • tingling of the hands and feet
  • ulceration of the skin
  • unusual tiredness or weakness
  • unusual weight gain or loss

Less common

  • Cough
  • fever


  • Change in vision
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain across part of your vision
  • stomach cramps, pain, or tenderness
  • watery or bloody diarrhea

Some side effects of trametinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Burning, itching, and pain in hairy areas, pus at the root of the hair
  • canker sores
  • change in taste
  • dark urine
  • dry eyes
  • dry mouth
  • dry skin
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loosening of the fingernails
  • loss of taste
  • muscle cramp, pain, stiffness, or spasm
  • redness or soreness around the fingernails
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • stomach pain
  • swelling or inflammation of the mouth
  • thirst

For Healthcare Professionals

Applies to trametinib: oral tablet


Very common (10% or more): Lymphedema/edema/peripheral edema (32%), hypertension (15%)

Common (1% to 10%): Left ventricular dysfunction, ejection fraction decreased, bradycardia, hypotension

Uncommon (0.1% to 1%): Cardiac failure, bradycardia

Frequency not reported: Myocarditis


Very common (10% or more): Rash (57%), acneiform dermatitis (19%), dry skin (11%), pruritus (10%), paronychia (10%), alopecia, erythema

Common (1% to 10%): Cellulitis, pustular rash, palmar-plantar erythrodysesthesia syndrome, skin fissures, chapped skin, folliculitis, actinic keratosis, night sweats, hyperkeratosis, skin lesion, hyperhidrosis, panniculitis, photosensitivity reaction

Uncommon (0.1% to 1%): Acrochordon (skin tags)


Very common (10% or more): Diarrhea (43%), stomatitis (15%), abdominal pain (13%), nausea, vomiting, dry mouth, constipation

Common (1% to 10%): Mucosal inflammation, stomatitis

Uncommon (0.1% to 1%): GI perforation, colitis, pancreatitis

Frequency not reported: Hematochezia, rectal hemorrhage, melena, gingival bleeding, hemorrhoidal hemorrhage


Very common (10% or more): Hemorrhage (13%), neutropenia

Common (1% to 10%): Anemia, thrombocytopenia, leukopenia


Very common (10% or more): Aspartate aminotransferase increased

Common (1% to 10%): Alanine aminotransferase increased


Very common (10% or more): Decreased appetite

Common (1% to 10%): Dehydration, blood alkaline phosphatase increased, blood creatine phosphokinase increased, hyperglycemia


Very common (10% or more): Arthralgia, myalgia, pain in extremity, muscle spasms

Uncommon (0.1% to 1%): Rhabdomyolysis

Nervous system

Very common (10% or more): Headache, dizziness


Common (1% to 10%): Blurred vision, periorbital edema, visual impairment

Uncommon (0.1% to 1%): Chorioretinopathy, papilledema, retinal detachment, retinal vein occlusion

Frequency not reported: Conjunctival hemorrhage


Common (1% to 10%): Hypersensitivity


Common (1% to 10%): Influenza-like illness


Very common (10% or more): Urinary tract infection

Frequency not reported: Vaginal hemorrhage, hematuria


Very common (10% or more): Nasopharyngitis, cough

Common (1% to 10%): Pneumonitis, dyspnea

Uncommon (0.1% to 1%): Interstitial lung disease

Frequency not reported: Epistaxis


Very common (10% or more): Fatigue, peripheral edema, shills, asthenia, pyrexia

Common (1% to 10%): Face edema, asthenia


Common (1% to 10%): Renal failure

Uncommon (0.1% to 1%): Nephritis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Mekinist