Note: This document contains side effect information about procarbazine. Some of the dosage forms listed on this page may not apply to the brand name Matulane.
Applies to procarbazine: oral capsule
Oral route (Capsule)
Adequate clinical and laboratory facilities should be available to patients treated with procarbazine for proper monitoring of treatment.
Along with their needed effects, medicines like procarbazine (the active ingredient contained in Matulane) can sometimes cause unwanted effects such as blood problems, loss of hair, high blood pressure reactions, and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.
Although not all of these side effects may occur, if they do occur they may need medical attention.
Stop taking procarbazine and get emergency help immediately if any of the following effects occur:
Check with your doctor immediately if any of the following side effects occur while taking procarbazine:
Check with your doctor as soon as possible if any of the following side effects occur while taking procarbazine:
Some side effects of procarbazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
This medicine may cause a temporary loss of hair in some people. After treatment with procarbazine has ended, normal hair growth should return.
Applies to procarbazine: oral capsule
Very common (10% or more): Leukopenia, anemia, thrombopenia
Frequency not reported: Pancytopenia, eosinophilia, hemolytic anemia, bleeding tendencies (e.g., petechiae, purpura, epistaxis, hemoptysis)
Very common (10% or more): Nausea, vomiting, anorexia
Frequency not reported: Stomatitis, hematemesis, melena, diarrhea, dysphagia, anorexia, abdominal pain, constipation, dry mouth
Frequency not reported: Headache, ataxia, slurred speech, drowsiness, coma, convulsions, neuropathy, paresthesia, nystagmus, diminished reflexes, falling, foot drop, dizziness, unsteadiness, tremors
Frequency not reported: Hypotension, tachycardia, syncope
Frequency not reported: Retinal hemorrhage, papilledema, photophobia, diplopia, inability to focus
Frequency not reported: Pneumonitis, pleural effusion, cough
Frequency not reported: Allergic skin reactions, diaphoresis, dermatitis, pruritus, alopecia, hyperpigmentation, rash, urticaria, flushing
Frequency not reported: Severe hypersensitivity reactions with angioedema, urticaria, and a precipitous drop in serum complement
Frequency not reported: Azoospermia, ovarian failure, gynecomastia (in prepubertal and early pubertal boys), hematuria, urinary frequency, nocturia
Frequency not reported: Myalgia, arthralgia
Frequency not reported: Insomnia, hallucinations, depression, apprehension, nervousness, confusion, nightmares
Frequency not reported: Lung cancer, acute myelocytic leukemia and malignant myelosclerosis
Frequency not reported: Lethargy, hearing loss, pyrexia, weakness, fatigue, edema, chills, hoarseness, pain
Frequency not reported: Infections, herpes
Frequency not reported: Jaundice, abnormal liver function tests
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Matulane