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Generic Name: procarbazine (pro CAR ba zeen)
Brand Name: Matulane
Physician reviewed Matulane patient information - includes Matulane description, dosage and directions.
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Drug Information:
Matulane is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Matulane is given with other cancer medicines to treat Hodgkin's Disease (a type of blood cancer). Matulane may also be used for purposes not listed in this medication guide. You should not take Matulane if you have bone marrow suppression. Matulane can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches). Learn more

Matulane Side Effects

Matulane Side Effects

Note: This document contains side effect information about procarbazine. Some of the dosage forms listed on this page may not apply to the brand name Matulane.

For the Consumer

Applies to procarbazine: oral capsule


Oral route (Capsule)

Adequate clinical and laboratory facilities should be available to patients treated with procarbazine for proper monitoring of treatment.

Along with their needed effects, medicines like procarbazine (the active ingredient contained in Matulane) can sometimes cause unwanted effects such as blood problems, loss of hair, high blood pressure reactions, and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking procarbazine and get emergency help immediately if any of the following effects occur:


  • Chest pain (severe)
  • enlarged pupils of eyes
  • fast or slow heartbeat
  • headache (severe)
  • increased sensitivity of eyes to light
  • increased sweating (possibly with fever or cold, clammy skin)
  • stiff or sore neck

Check with your doctor immediately if any of the following side effects occur while taking procarbazine:

Less common

  • Black, tarry stools
  • blood in urine or stools
  • bloody vomit
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Check with your doctor as soon as possible if any of the following side effects occur while taking procarbazine:

More common

  • Confusion
  • convulsions (seizures)
  • cough
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • missing menstrual periods
  • shortness of breath
  • thickening of bronchial secretions
  • tiredness or weakness (continuing)

Less common

  • Diarrhea
  • sores in mouth and on lips
  • tingling or numbness of fingers or toes
  • unsteadiness or awkwardness
  • yellow eyes or skin


  • Fainting
  • skin rash, hives, or itching
  • wheezing

Some side effects of procarbazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Drowsiness
  • muscle or joint pain
  • muscle twitching
  • nausea and vomiting
  • nervousness
  • nightmares
  • trouble in sleeping
  • unusual tiredness or weakness

Less common

  • Constipation
  • darkening of skin
  • difficulty in swallowing
  • dizziness or lightheadedness when getting up from a lying or sitting position
  • dry mouth
  • feeling of warmth and redness in face
  • headache
  • loss of appetite
  • mental depression

This medicine may cause a temporary loss of hair in some people. After treatment with procarbazine has ended, normal hair growth should return.

For Healthcare Professionals

Applies to procarbazine: oral capsule


Very common (10% or more): Leukopenia, anemia, thrombopenia

Frequency not reported: Pancytopenia, eosinophilia, hemolytic anemia, bleeding tendencies (e.g., petechiae, purpura, epistaxis, hemoptysis)


Very common (10% or more): Nausea, vomiting, anorexia

Frequency not reported: Stomatitis, hematemesis, melena, diarrhea, dysphagia, anorexia, abdominal pain, constipation, dry mouth

Nervous system

Frequency not reported: Headache, ataxia, slurred speech, drowsiness, coma, convulsions, neuropathy, paresthesia, nystagmus, diminished reflexes, falling, foot drop, dizziness, unsteadiness, tremors


Frequency not reported: Hypotension, tachycardia, syncope


Frequency not reported: Retinal hemorrhage, papilledema, photophobia, diplopia, inability to focus


Frequency not reported: Pneumonitis, pleural effusion, cough


Frequency not reported: Allergic skin reactions, diaphoresis, dermatitis, pruritus, alopecia, hyperpigmentation, rash, urticaria, flushing


Frequency not reported: Severe hypersensitivity reactions with angioedema, urticaria, and a precipitous drop in serum complement


Frequency not reported: Azoospermia, ovarian failure, gynecomastia (in prepubertal and early pubertal boys), hematuria, urinary frequency, nocturia


Frequency not reported: Myalgia, arthralgia


Frequency not reported: Insomnia, hallucinations, depression, apprehension, nervousness, confusion, nightmares


Frequency not reported: Lung cancer, acute myelocytic leukemia and malignant myelosclerosis


Frequency not reported: Lethargy, hearing loss, pyrexia, weakness, fatigue, edema, chills, hoarseness, pain


Frequency not reported: Infections, herpes


Frequency not reported: Jaundice, abnormal liver function tests

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Matulane