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Marqibo

Generic Name: vincristine liposome (vin KRIS teen LYE poe some)
Brand Names: Marqibo
Marqibo (vincristine sulfate liposome injection) is used to treat Philadelphia chromosome negative acute lymphoblastic leukemia. Learn about side effects, interactions and indications.
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Drug Information:
Marqibo (vincristine liposome) is cancer medication that interferes with the growth of cancer cells and slows their spread in the body. Marqibo is used to treat a type of blood cancer called Philadelphia chromosome negative acute lymphoblastic leukemia (ALL). It is usually given after at least two other cancer medications have been tried without success. Marqibo may also be used for purposes not listed in this medication guide. You should not use Marqibo if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord). Learn more

Marqibo Side Effects

Marqibo Side Effects

Note: This document contains side effect information about vincristine liposome. Some of the dosage forms listed on this page may not apply to the brand name Marqibo.

In Summary

Common side effects of Marqibo include: anemia, constipation, neutropenia, and thrombocytopenia. Other side effects include: asthenia, increased serum aspartate aminotransferase, and intestinal obstruction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vincristine liposome: intravenous suspension

Warning

Intravenous route (Suspension)

For intravenous use only. Fatalities have occurred when given by other routes, including intrathecal administration. VinCRIStine sulfate liposome injection has different dosage recommendations than vinCRIStine sulfate injection. Verify drug name and dose before preparation and administration to avoid overdosage.

Along with its needed effects, vincristine liposome (the active ingredient contained in Marqibo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vincristine liposome:

More common

  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • change in consciousness
  • change in muscle reflexes
  • chest pain
  • chills
  • confusion
  • cough
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • increased sensitivity to pain or touch
  • low blood pressure or pulse
  • lower back or side pain
  • nerve pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sensation of pins and needles
  • severe constipation
  • severe vomiting
  • shortness of breath
  • sneezing
  • sore throat
  • stabbing pain
  • sweating
  • tightness in the chest
  • troubled breathing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Blue lips, fingernails, or skin
  • irregular, fast or slow, or shallow breathing

Incidence not known

  • Abdominal or stomach tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • headache
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • yellow eyes or skin

Some side effects of vincristine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Lack or loss of strength
  • mental depression or anxiety
  • muscle weakness
  • nightmares or unusually vivid dreams

Incidence not known

  • Redness, pain, or swelling at the injection site

For Healthcare Professionals

Applies to vincristine liposome: intravenous kit

Cardiovascular

Common (1% to 10%): Hypotension, cardiac arrest, vascular disorder

Gastrointestinal

Very common (10% or more): Nausea (52%), diarrhea (37%), decreased appetite (33%)

Common (1% to 10%): Constipation, abdominal pain, ileus/colonic pseudo-obstruction

General

Side effects that have resulted in non-leukemia related deaths: Brain infarct, intracerebral hemorrhage, liver failure, multisystem organ failure, pneumonia and septic shock, respiratory failure, pulmonary hemorrhage, sudden cardiac death

Hematologic

Very common (10% or more): Febrile neutropenia (38%), neutropenia (31.3%), anemia (34%), thrombocytopenia (16.9%)

Frequency not reported: Neutropenia, thrombocytopenia

Metabolic

Frequency not reported: Increased aspartate aminotransferase, tumor lysis syndrome

Musculoskeletal

Frequency not reported: Asthenia, muscular weakness, musculoskeletal pain

Nervous system

Very common (10% or more): Peripheral neuropathy (39%), insomnia (32%)

Common (1% to 10%): Peripheral sensory and motor neuropathy, decreased vibratory sense, facial palsy, hyporeflexia, asthenia

Other

Very common (10% or more): Pyrexia (15%), fatigue (12%)

Psychiatric

Frequency not reported: Mental status changes

Respiratory

Common (1% to 10%): Respiratory distress, respiratory failure, pneumonia

Immunologic

Common (1% to 10%): Septic shock, staphylococcal bacteremia

Local

Frequency not reported: Extravasation tissue injury

Hepatic

Frequency not reported: Hepatic toxicity

Oncologic

Very common (10% or more): Pyrexia (43%), fatigue (41%)

Frequency not reported: Pain, septic shock, staphylococcal bacteremia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Marqibo