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Lynparza

Generic Name: olaparib (oh LAP a rib)
Brand Names: Lynparza
Lynparza (olaparib) is used to treat ovarian cancer, breast cancer and pancreatic cancer. Includes Lynparza side effects, interactions and indications.
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Drug Information:
Lynparza (olaparib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Lynparza is used to treat advanced ovarian cancer in women with a certain abnormal inherited gene who have responded to platinum chemotherapy. Lynparza is also used to help maintain your body's response to prior chemotherapy for ovarian cancer, fallopian tube cancer, or peritoneal cancer when the cancer has come back. Lynparza is also used to treat HER2-negative breast cancer that has spread to other parts of the body before or after prior chemotherapy or hormonal treatment. Learn more

Lynparza Side Effects

Lynparza Side Effects

Note: This document contains side effect information about olaparib. Some of the dosage forms listed on this page may not apply to the brand name Lynparza.

In Summary

Common side effects of Lynparza include: upper respiratory tract infection, anemia, decreased hemoglobin, increased mcv, increased serum creatinine, nasopharyngitis, nausea, pharyngitis, vomiting, cough, and dyspnea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olaparib: oral tablet

Along with its needed effects, olaparib (the active ingredient contained in Lynparza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olaparib:

More common

  • Chest pain
  • chills
  • cough
  • ear congestion or pain
  • fever
  • head congestion
  • hoarseness or other voice changes
  • nasal congestion
  • pale skin
  • runny nose
  • sneezing
  • sore throat
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Lower back or side pain
  • painful or difficult urination
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands

Some side effects of olaparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • cracked, dry, or scaly skin
  • decreased appetite
  • diarrhea
  • difficulty with moving
  • dry mouth
  • fear or nervousness
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • heartburn
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • lack or loss of strength
  • loss of bladder control
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • stomach discomfort, upset, or pain
  • sweating
  • swelling or inflammation of the mouth
  • trouble sleeping
  • unexplained weight loss
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to olaparib: oral capsule, oral tablet

Oncologic

Uncommon (0.1% to 1%): Myelodysplastic syndrome/Acute Myeloid Leukemia

Hematologic

Very common (10% or more): Decreased hemoglobin (up to 90%), elevated mean corpuscular volume (up to 85%), decreased lymphocytes (up to 56%), anemia (up to 34%), decreased absolute neutrophil count (up to 32%), decreased platelets (up to 30%)

Common (1% to 10%): Leukopenia

Respiratory

Very common (10% or more): Nasopharyngitis/pharyngitis/upper respiratory infection (up to 43%), cough (up to 21%), dyspnea

Common (1% to 10%): Pulmonary embolism

Uncommon (0.1% to 1%): Pneumonitis

Gastrointestinal

Very common (10% or more): Nausea (up to 75%), abdominal pain/discomfort (up to 47%), vomiting (up to 43%), diarrhea (up to 31%), dyspepsia (up to 25%), constipation

Common (1% to 10%): Stomatitis

Other

Very common (10% or more): Fatigue/asthenia/lethargy (up to 68%), peripheral edema

Common (1% to 10%): Pyrexia

Renal

Very common (10% or more): Increased creatinine (up to 30%)

Musculoskeletal

Very common (10% or more): Arthralgia/musculoskeletal pain (up to 32%), myalgia (up to 25%), back pain (up to 25%)

Cardiovascular

Common (1% to 10%): Hypertension, hot flush, venous thrombosis

Dermatologic

Very common (10% or more): Dermatitis/rash (up to 25%)

Common (1% to 10%): Dry skin, eczema, pruritus

Genitourinary

Very common (10% or more): Urinary tract infection

Common (1% to 10%): Dysuria, urinary incontinence, vulvovaginal disorder

Metabolic

Very common (10% or more): Decreased appetite (up to 25%)

Common (1% to 10%): Hypomagnesemia, hyperglycemia

Nervous system

Very common (10% or more): Headache (up to 25%), dysgeusia (up to 21%), dizziness

Common (1% to 10%): Peripheral neuropathy

Psychiatric

Common (1% to 10%): Anxiety, depression, insomnia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Lynparza