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Generic Name: ranibizumab (ophthalmic) (ra NIB i ZUE mab off THAL mik)
Brand Names: Lucentis
Lucentis is used to treat the wet form of age-related macular degeneration. Learn about side effects, interactions and indications.
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Drug Information:
Lucentis (ranibizumab) is made from a human antibody fragment. It works by keeping new blood vessels from forming under the retina (a sensory membrane that lines the inside of the eye). In people with certain types of eye disorders, new blood vessels grow under the retina where they leak blood and fluid. Lucentis is used to treat the "wet form" of age-related macular degeneration. Lucentis is also used to treat swelling in the retina caused by diabetes or by a blockage in the blood vessels. You should not receive Lucentis if you are allergic to ranibizumab, or if you have any type of infection in or around your eyes. Learn more

Lucentis Side Effects

Lucentis Side Effects

Note: This document contains side effect information about ranibizumab ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Lucentis.

In Summary

Common side effects of Lucentis include: cataract, increased intraocular pressure, and intraocular inflammation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ranibizumab ophthalmic: intraocular solution

Along with its needed effects, ranibizumab ophthalmic (the active ingredient contained in Lucentis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ranibizumab ophthalmic:

More common

  • Blindness
  • bloody eye
  • blurred vision or loss of vision
  • decreased vision or other changes in vision
  • disturbed color perception
  • dizziness
  • double vision
  • dry eye
  • eye pain
  • fainting
  • feeling of having something in the eye
  • halos around lights
  • headache
  • night blindness
  • overbright appearance of lights
  • pain or tenderness around the eyes and cheekbones
  • red, sore eyes
  • redness of the white part of the eyes or inside of the eyelids
  • redness, swelling, or itching of the eyelid
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across a part of vision
  • sensitivity of the eye to light
  • tearing of the eyes
  • tunnel vision
  • watering of the eyes

Less common

  • Body aches or pain
  • chest pain
  • chills
  • cough
  • difficulty with breathing
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • general feeling of discomfort or illness
  • head congestion
  • hoarseness, loss of voice, or other voice changes
  • loss of consciousness
  • muscle aches and pains
  • nasal congestion
  • pain in the chest, groin, or legs, especially the calves
  • painful blisters on the trunk of the body
  • pale skin
  • runny nose
  • severe, sudden headache
  • shivering
  • slow wound healing
  • slurred speech
  • sneezing
  • sore throat
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • sweating
  • tightness in the chest
  • trouble sleeping
  • unexplained weight loss
  • unusual tiredness or weakness

Some side effects of ranibizumab ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • muscle stiffness
  • swelling or redness in the joints

For Healthcare Professionals

Applies to ranibizumab ophthalmic: intravitreal solution


-Very common (10% or more): Conjunctival hemorrhage (up to 74%), eye pain (up to 35%), vitreous floaters (up to 27%), increased intraocular pressure (up to 24%), vitreous detachment (up to 21%), intraocular inflammation (up to 18%), vision disturbance/blurred vision (up to 18%), cataract (up to 17%), foreign body sensation in eyes (up to 16%), eye irritation (up to 15%), increased lacrimation (up to 14%), blepharitis (up to 12%), dry eye (up to 12%), eye pruritus (up to 12%), ocular hyperemia (up to 11%), maculopathy (up to 11%), retinal disorder (10%), vitreitis, retinal hemorrhage

-Common (1% to 10%): Retinal degeneration, retinal detachment, retinal tear, retinal pigment epithelium detachment, retinal pigment epithelium tear, reduced visual acuity, vitreous hemorrhage, vitreous disorder, uveitis, iritis, iridocyclitis, subcapsular cataract, punctuate keratitis, corneal abrasion, anterior chamber flare, eye hemorrhage, conjunctivitis, allergic conjunctivitis, eye discharge, photopsia, photophobia, ocular discomfort, eyelid edema, eyelid pain, conjunctival hyperemia, posterior capsule opacification, endophthalmitis, injection site hemorrhage

-Uncommon (0.1% to 1%): Blindness, endophthalmitis, hypopyon, hyphema, keratopathy, iris adhesion, corneal deposits, corneal edema, corneal striae, injection site pain, injection site irritation, abnormal sensation in eye, eyelid irritation


Very common (10% or more): Nasopharyngitis (up to 16%), bronchitis (up to 11%)

Common (1% to 10%): Cough, upper respiratory tract infection, sinusitis, chronic obstructive pulmonary disease

Nervous system

Very common (10% or more): Headache (up to 12%)

Common (1% to 10%): Peripheral neuropathy, stroke


Very common (10% or more): Anemia (up to 11%)


Very common (10% or more): Arthralgia (up to 11%)


Very common (10% or more): Arterial thromboembolic events (up to 10.8%)

Common (1% to 10%): Peripheral edema, atrial fibrillation


Very common (10% or more): Nausea (up to 10%)

Common (1% to 10%): Constipation, gastroesophageal reflux disease


Common (1% to 10%): Urinary tract infection


Common (1% to 10%): Hypersensitivity reactions


Common (1% to 10%): Immunoreactivity, seasonal allergy, allergic reactions (rash, urticaria, pruritus, erythema)


Common (1% to 10%): Hypercholesterolemia


Common (1% to 10%): Influenza, would healing complications, fatal events

Frequency not reported: Non-ocular hemorrhage


Common (1% to 10%): Anxiety


Common (1% to 10%): Renal failure, chronic renal failure

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Lucentis