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Generic Name: chlorzoxazone (klor ZOX a zone)
Brand Name: Lorzone, Paraflex, Remular-S
Physician reviewed Lorzone patient information - includes Lorzone description, dosage and directions.
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Drug Information:
Lorzone is a muscle relaxer that is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Lorzone may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use Lorzone if you are allergic to it. Tell your doctor if you have ever had: liver disease. Tell your doctor if you are pregnant or breast-feeding. Learn more

Lorzone Side Effects

Lorzone Side Effects

Note: This document contains side effect information about chlorzoxazone. Some of the dosage forms listed on this page may not apply to the brand name Lorzone.

For the Consumer

Applies to chlorzoxazone: oral tablet

Along with its needed effects, chlorzoxazone (the active ingredient contained in Lorzone) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlorzoxazone:


  • Bloody or black, tarry stools
  • clay-colored stools
  • constipation
  • cough
  • dark urine
  • decreased appetite
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • nausea and vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe stomach pain
  • shortness of breath
  • skin rash
  • swelling of the feet or lower legs
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking chlorzoxazone:

Symptoms of overdose

  • Diarrhea
  • difficult or troubled breathing
  • drowsiness
  • general feeling of discomfort or illness
  • headache
  • irregular, fast or slow, or shallow breathing
  • lightheadedness
  • nausea
  • pale or blue lips, fingernails, or skin
  • sluggishness
  • vomiting

Some side effects of chlorzoxazone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Bruising
  • large, flat, blue, or purplish patches in the skin
  • small red or purple spots on the skin

For Healthcare Professionals

Applies to chlorzoxazone: compounding powder, oral tablet


Adverse reactions such as gastrointestinal disturbances, drowsiness, dizziness, or lightheadedness may occur.


Frequency not reported: Gastrointestinal disturbances, gastrointestinal bleeding


Rarely skin hypersensitivity type reactions such as skin rashes, petechiae, and ecchymosis have develop; extremely rare reports of angioneurotic edema and anaphylactic reactions have been received.

Frequency not reported: Allergic-type skin rashes, petechiae, ecchymosis, angioneurotic edema, anaphylactic reactions

Nervous system

Frequency not reported: Drowsiness, dizziness, light-headedness, malaise, and overstimulation.


Urine discoloration attributed to a phenolic metabolite have been reported; the clinical significance of this is unknown.

Rare (less than 0.1%): Urine discoloration

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Lorzone