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Generic Name: tipiracil and trifluridine (tye PIR a sil and trye FLURE i deen)
Brand Names: Lonsurf
Lonsurf (trifluridine and tipiracil) is used to treat advanced colorectal cancer. Includes Lonsurf side effects, interactions and indications.
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Drug Information:
Lonsurf contains a combination of tipiracil and trifluridine. Tipiracil and trifluridine are anti-cancer medicines that interfer with the growth and spread of cancer cells in the body. Lonsurf is used to treat colorectal cancer that has spread to other parts of the body (metastatic). Lonsurf is also used to treat a type of stomach cancer called gastric cancer, including adenocarcinoma of the gastroesophageal junction, that has spread to other parts of the body (metastatic). Lonsurf is usually given after other cancer medicines have been tried without success. Learn more

Lonsurf Side Effects

Lonsurf Side Effects

Note: This document contains side effect information about tipiracil / trifluridine. Some of the dosage forms listed on this page may not apply to the brand name Lonsurf.

In Summary

Common side effects of Lonsurf include: infection, anemia, asthenia, diarrhea, fatigue, fever, nausea, neutropenia, thrombocytopenia, vomiting, and decreased appetite. Other side effects include: alopecia, and dysgeusia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tipiracil / trifluridine: oral tablet

Along with its needed effects, tipiracil / trifluridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tipiracil / trifluridine:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Bladder pain
  • bloody or cloudy urine
  • frequent urge to urinate
  • headache
  • muscle aches
  • stuffy or runny nose

Some side effects of tipiracil / trifluridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • change in taste
  • decreased appetite
  • diarrhea
  • hair loss or thinning of the hair
  • lack or loss of strength
  • loss of taste
  • nausea
  • swelling or inflammation of the mouth
  • vomiting

For Healthcare Professionals

Applies to tipiracil / trifluridine: oral tablet


Very common (10% or more): Anemia (77%), neutropenia (67%), thrombocytopenia (42%)

Common (1% to 10%): Febrile neutropenia


Very common (10% or more): Asthenia/fatigue (52%), infections (27%), pyrexia (19%)


Very common (10% or more): Nausea (48%), diarrhea (32%), vomiting (28%), abdominal pain (21%)

Common (1% to 10%): Stomatitis (8%)


Common (1% to 10%): Nasopharyngitis, pulmonary emboli

Uncommon (0.1% to 1%): Interstitial lung disease


Very common (10% or more): Decreased appetite (39%)


Common (1% to 10%): QTc interval prolongation

Nervous system

Common (1% to 10%): Dysgeusia


Common (1% to 10%): Urinary tract infections


Common (1% to 10%): Alopecia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Lonsurf