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Generic Name: linaclotide (LIN a KLOE tide)
Brand Names: Linzess
Linzess (linaclotide) is used to treat chronic idiopathic constipation and to treat irritable bowel syndrome with constipation (IBS-C). Includes Linzess side effects, interactions and indications.
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Drug Information:
Linzess (linaclotide) works by increasing the secretion of chloride and water in the intestines, which can soften stools and stimulate bowel movements. Linzess is a prescription medicine used to treat chronic constipation, or chronic irritable bowel syndrome (IBS) in adults who have had constipation as the main symptom. The safety and effectiveness of Linzess has not been established in patients under 18 years of age. You should not use Linzess if you have a blockage in your intestines. Linzess should not be given to a child younger than 6 years old. Linaclotide can cause severe dehydration in a child. Learn more

Linzess Side Effects

Linzess Side Effects

Note: This document contains side effect information about linaclotide. Some of the dosage forms listed on this page may not apply to the brand name Linzess.

In Summary

Common side effects of Linzess include: diarrhea. Other side effects include: flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to linaclotide: oral capsule


Oral route (Capsule)

Linaclotide is contraindicated in pediatric patients up less than 6 years of age; in nonclinical studies in neonatal mice, administration of a single, clinically relevant adult oral dose of linaclotide caused deaths due to dehydration. Avoid use of linaclotide in pediatric patients 6 to less than 18 years of age. The safety and efficacy of linaclotide has not been established in pediatric patients under 18 years of age.

Along with its needed effects, linaclotide (the active ingredient contained in Linzess) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking linaclotide:

More common

  • Abdominal or stomach pain
  • severe diarrhea

Less common

  • Heartburn
  • loss of appetite
  • nausea
  • vomiting
  • weakness


  • Bleeding from the rectum
  • bloody, black, or tarry stools
  • confusion
  • cough
  • decreased urination
  • difficulty swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast heartbeat
  • hives or welts, itching, or skin rash or redness
  • increase in heart rate
  • lightheadedness
  • loss of bowel control
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid breathing
  • shortness of breath
  • sunken eyes
  • thirst
  • tightness in the chest
  • unusual tiredness or weakness
  • wrinkled skin

Some side effects of linaclotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • chills
  • ear congestion
  • excess air or gas in the stomach or intestines
  • fever
  • full or bloated feeling
  • headache
  • loss of voice
  • passing gas
  • sneezing
  • sore throat
  • stuffy or runny nose

Less common

  • Acid or sour stomach
  • belching
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • pressure in the stomach
  • stomach discomfort or upset
  • swelling of the abdominal or stomach area

For Healthcare Professionals

Applies to linaclotide: oral capsule


Very common (10% or more): Diarrhea (up to 20%)

Common (1% to 10%): Abdominal pain, flatulence, abdominal distension, viral gastroenteritis, gastroesophageal reflux disease, vomiting, fecal incontinence, dyspepsia

Uncommon (0.1% to 1%): Defecation urgency


Uncommon (0.1% to 1%): Orthostatic hypotension


Uncommon (0.1% to 1%): Urticaria

Frequency not reported: Rash


The most commonly reported reasons for treatment discontinuation were diarrhea and abdominal pain.


Uncommon (0.1% to 1%): Hematochezia, melena, rectal hemorrhage


Uncommon (0.1% to 1%): Allergic reactions


Uncommon (0.1% to 1%): Dehydration, hypokalemia, decreased appetite

Rare (less than 0.1%): Decreased blood bicarbonate

Nervous system

Common (1% to 10%): Headache, dizziness


Common (1% to 10%): Fatigue


Common (1% to 10%): Upper respiratory tract infection, sinusitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Linzess