Note: This document contains side effect information about lincomycin. Some of the dosage forms listed on this page may not apply to the brand name Lincocin.
Applies to lincomycin: injection solution
Injection route (Solution)
Clostridium difficile associated diarrhea (CDAD) has been reported with nearly all antibacterial agents, including lincomycin, and may range in severity from mild diarrhea to fatal colitis. Therefore, lincomycin therapy should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C difficile may need to be discontinued. Appropriate supportive therapy, such as fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation should be instituted as clinically indicated.
Along with its needed effects, lincomycin (the active ingredient contained in Lincocin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking lincomycin:
Incidence not known
Some side effects of lincomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to lincomycin: compounding powder, injectable solution, oral capsule
The onset of pseudomembranous colitis symptoms has been reported during and after antibacterial therapy.
Esophagitis was reported with oral preparations.
Frequency not reported: Glossitis, stomatitis, nausea, vomiting, abdominal distress, persistent diarrhea, enterocolitis, antibacterial-associated diarrhea and colitis, pruritus ani, pseudomembranous colitis, Clostridium difficile associated diarrhea, esophagitis
Some hypersensitivity reactions occurred in penicillin-sensitive patients.
A 19-year-old male patient, who had received 2 previous IM injections of lincomycin (the active ingredient contained in Lincocin) at the age of 17 years and 1 IM injection 2 weeks prior, reported that a few minutes after his fourth IM injection he noticed a tingling sensation around his face and mouth. The patient's symptoms progressed to bright red to blue-violet skin discoloration, injection of the bulbar conjunctivae, and swelling of his face, neck, and ears. The patient recovered without incident after receiving adrenaline and betamethasone IM followed by oral prednisone with an antihistamine.
Frequency not reported: Hypersensitivity reactions (such as angioneurotic edema, serum sickness, anaphylaxis); face, ears, and neck swelling
Rare (less than 0.1%): Exfoliative and vesiculobullous dermatitis
Frequency not reported: Skin rashes, urticaria, pruritus, erythema multiforme (some resembling Stevens-Johnson syndrome)
Rare (less than 0.1%): Aplastic anemia, pancytopenia
Frequency not reported: Neutropenia, leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura
Rare (less than 0.1%): Cardiopulmonary arrest
Frequency not reported: Hypotension
Cases of hypotension after parenteral administration have been reported, especially after too rapid IV administration. Rare cases of cardiopulmonary arrest have been reported after this drug was administered IV too rapidly. In these cases, the affected patients subsequently tolerated slow infusions. A study that looked at multiple large dose administration of this drug found that when the doses were appropriately diluted and administered more slowly, cardiovascular changes did not occur.
Frequency not reported: Jaundice, abnormal liver function tests (especially elevated serum transaminase)
Rare (less than 0.1%): Renal dysfunction, azotemia, oliguria
Rare (less than 0.1%): Proteinuria
Frequency not reported: Vaginitis
Frequency not reported: Tinnitus, vertigo, neuromuscular blockade, metallic taste in mouth
Frequency not reported:
-IM: Pain following injection, local irritation, pain induration, sterile abscess formation
Frequency not reported: Bulbar conjunctival injection
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Lincocin