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Generic Name: Lincomycin (lin koe MYE sin)
Brand Name: Lincocin
Easy-to-read patient leaflet for Lincocin. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Lincocin (lincomycin). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Lincocin (lincomycin) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Lincocin (lincomycin) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Lincocin Side Effects

Lincocin Side Effects

Note: This document contains side effect information about lincomycin. Some of the dosage forms listed on this page may not apply to the brand name Lincocin.

For the Consumer

Applies to lincomycin: injection solution


Injection route (Solution)

Clostridium difficile associated diarrhea (CDAD) has been reported with nearly all antibacterial agents, including lincomycin, and may range in severity from mild diarrhea to fatal colitis. Therefore, lincomycin therapy should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C difficile may need to be discontinued. Appropriate supportive therapy, such as fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation should be instituted as clinically indicated.

Along with its needed effects, lincomycin (the active ingredient contained in Lincocin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lincomycin:

Incidence not known

  • Abdominal or stomach pain or tenderness
  • black, tarry stools
  • blistering, peeling, or loosening of the skin
  • blurred vision
  • chills
  • clay-colored stools
  • confusion
  • cough
  • dark urine
  • diarrhea
  • difficulty with swallowing
  • dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • fever
  • headache
  • hives, itching, or rash
  • joint or muscle pain
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • severe abdominal or stomach cramps and pain
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • tightness in the chest
  • ulcers, sores, or white spots in the mouth
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • watery and severe diarrhea, which may also be bloody
  • yellow eyes or skin

Some side effects of lincomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Abdominal or stomach discomfort
  • continuing ringing or buzzing or other unexplained noise in the ears
  • feeling of constant movement of self or surroundings
  • hearing loss
  • pain, redness, or hard lumps at the injection site
  • redness, swelling, or soreness of the tongue
  • sensation of spinning
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lincomycin: compounding powder, injectable solution, oral capsule


The onset of pseudomembranous colitis symptoms has been reported during and after antibacterial therapy.

Esophagitis was reported with oral preparations.

Frequency not reported: Glossitis, stomatitis, nausea, vomiting, abdominal distress, persistent diarrhea, enterocolitis, antibacterial-associated diarrhea and colitis, pruritus ani, pseudomembranous colitis, Clostridium difficile associated diarrhea, esophagitis


Some hypersensitivity reactions occurred in penicillin-sensitive patients.

A 19-year-old male patient, who had received 2 previous IM injections of lincomycin (the active ingredient contained in Lincocin) at the age of 17 years and 1 IM injection 2 weeks prior, reported that a few minutes after his fourth IM injection he noticed a tingling sensation around his face and mouth. The patient's symptoms progressed to bright red to blue-violet skin discoloration, injection of the bulbar conjunctivae, and swelling of his face, neck, and ears. The patient recovered without incident after receiving adrenaline and betamethasone IM followed by oral prednisone with an antihistamine.

Frequency not reported: Hypersensitivity reactions (such as angioneurotic edema, serum sickness, anaphylaxis); face, ears, and neck swelling


Rare (less than 0.1%): Exfoliative and vesiculobullous dermatitis

Frequency not reported: Skin rashes, urticaria, pruritus, erythema multiforme (some resembling Stevens-Johnson syndrome)


Rare (less than 0.1%): Aplastic anemia, pancytopenia

Frequency not reported: Neutropenia, leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura


Rare (less than 0.1%): Cardiopulmonary arrest

Frequency not reported: Hypotension

Cases of hypotension after parenteral administration have been reported, especially after too rapid IV administration. Rare cases of cardiopulmonary arrest have been reported after this drug was administered IV too rapidly. In these cases, the affected patients subsequently tolerated slow infusions. A study that looked at multiple large dose administration of this drug found that when the doses were appropriately diluted and administered more slowly, cardiovascular changes did not occur.


Frequency not reported: Jaundice, abnormal liver function tests (especially elevated serum transaminase)


Rare (less than 0.1%): Renal dysfunction, azotemia, oliguria


Rare (less than 0.1%): Proteinuria

Frequency not reported: Vaginitis

Nervous system

Frequency not reported: Tinnitus, vertigo, neuromuscular blockade, metallic taste in mouth


Frequency not reported:

-IM: Pain following injection, local irritation, pain induration, sterile abscess formation

-IV: Thrombophlebitis


Frequency not reported: Bulbar conjunctival injection

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Lincocin