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Generic Name: norepinephrine (nor ep i NEF rin)
Brand Name: Levophed
Physician reviewed Levophed patient information - includes Levophed description, dosage and directions.
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Drug Information:
Levophed is similar to adrenaline. It is used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures. This medicine is often used during CPR (cardio-pulmonary resuscitation). Levophed may also be used for purposes not listed in this medication guide. Tell your caregivers at once if you have a serious side effect such as a cold feeling anywhere in your body, blue lips or fingernails, trouble breathing, little or no urination, irritation or skin changes where the medicine was injected, slow heart rate, sudden numbness or weakness, severe headache, or problems with vision, speech, or balance. Learn more

Levophed Side Effects

Levophed Side Effects

Note: This document contains side effect information about norepinephrine. Some of the dosage forms listed on this page may not apply to the brand name Levophed.

For the Consumer

Applies to norepinephrine: parenteral injection


    Extravasation Risk
  • Phentolamine is the local antidote for peripheral ischemia resulting from extravasation of norepinephrine.

  • Phentolamine should be given as soon as possible after extravasation is noted.

  • Infiltrate the affected area (using a syringe with a fine hypodermic needle) liberally throughout as soon as possible with 10–15 mL of 0.9% sodium chloride injection containing 5–10 mg of phentolamine mesylate (an α-adrenergic blocking agent) to prevent sloughing and necrosis in ischemic areas.

  • Sympathetic blockade with phentolamine causes immediate and conspicuous local hyperemic changes if the area is infiltrated within 12 hours.

Side effects include:

May cause headache, anxiety, arrhythmias, bradycardia, respiratory difficulty, ischemic injury, or extravasation at the infusion site.

For Healthcare Professionals

Applies to norepinephrine: injectable solution, intravenous solution


If plasma volumes are not corrected, hypotension may recur when this drug is discontinued, or blood pressure may be maintained at the risk of severe peripheral and visceral vasoconstriction (e.g., decreased renal perfusion) with diminution in blood flow and tissue perfusion with subsequent tissue hypoxia and lactic acidosis and possible ischemic injury. Overdoses or conventional doses in hypersensitive patients (e.g., hyperthyroid patients) can cause severe hypertension with violent headache, photophobia, stabbing retrosternal pain, pallor, intense sweating, and vomiting.


Frequency not reported: Extravasation necrosis


Frequency not reported: Ischemic injury, bradycardia, arrhythmia, blood pressure increased, hypertension, pallor, stabbing retrosternal pain

Nervous system

Frequency not reported: Headache


Frequency not reported: Sweating


Frequency not reported: Vomiting


Frequency not reported: Photophobia


Frequency not reported: Plasma volume depletion


Frequency not reported: Anxiety


Frequency not reported: Respiratory difficulty, dyspnea


Frequency not reported: Gangrene

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Levophed