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Leukine

Generic Name: sargramostim (sar GRA moe stim)
Brand Names: Leukine
Leukine increases white blood cells and decreases the risk of infection in conditions such as cancer and bone marrow transplant. Learn about side effects, interactions and indications.
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Drug Information:
Leukine (sargramostim) is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection. Leukine is used in adults and children who are at least 2 years old, to help prevent serious infection in conditions such as leukemia, bone marrow transplant, and pre-chemotherapy blood cell collection. Leukine is also used to lower the risk of death from bone marrow suppression after exposure to radiation in adults and children as young as newborns. Learn more

Leukine Side Effects

Leukine Side Effects

Note: This document contains side effect information about sargramostim. Some of the dosage forms listed on this page may not apply to the brand name Leukine.

For the Consumer

Applies to sargramostim: injection powder for solution

Along with its needed effects, sargramostim (the active ingredient contained in Leukine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sargramostim:

More common

  • Black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the eye
  • bloody nose
  • blurred vision
  • body aches or pain
  • bone pain
  • chest pain
  • cloudy urine
  • congestion
  • cough
  • decrease in urine output or decrease in urine-concentrating ability
  • difficult or labored breathing
  • drowsiness
  • dry mouth
  • dryness or soreness of the throat
  • eye pain
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • hoarseness
  • increased hunger
  • increased thirst
  • increased urination
  • irregular heartbeat
  • large amount of cholesterol in the blood
  • loss of appetite
  • mood or mental changes
  • muscle spasms
  • nausea
  • rapid weight gain
  • redness in whites of eyes
  • runny nose
  • stomach pain
  • sweating
  • tender, swollen glands in the neck
  • tightness in the chest
  • tingling of the hands or feet
  • trouble with swallowing
  • trembling
  • twitching
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • voice changes
  • vomiting
  • vomiting of blood or material that looks like coffee grounds
  • yellow eyes or skin

Incidence not known

  • Chills
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • general feeling of illness
  • headache
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg

Some side effects of sargramostim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • difficulty in moving
  • fear or nervousness
  • itching skin
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in the joints
  • trouble sleeping

Incidence not known

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to sargramostim: injectable powder for injection, injectable solution

General

The type and frequency of adverse events following induction in patients with acute myelogenous leukemia (AML) were similar between those treated with this drug and those taking placebo.

Other

Very common (10% or more): Fever (up to 95%), mucous membrane disorder (75%), asthenia (up to 66%), malaise (57%), edema (up to 34%), chills (up to 25%), pain (17%), chest pain (15%), peripheral edema (up to 15%)

Gastrointestinal

Very common (10% or more): Nausea (up to 90%), diarrhea (up to 89%), vomiting (up to 85%), stomatitis (up to 62%), abdominal pain (38%), gastrointestinal disorder (37%), gastrointestinal hemorrhage (up to 27%), dyspepsia (17%), hematemesis (13%), dysphagia (11%)

Common (1% to 10%): Constipation, abdominal distention

Dermatologic

Very common (10% or more): Alopecia (up to 73%), rash (up to 70%), pruritus (23%)

Common (1% to 10%): Petechia, sweats

Immunologic

Very common (10% or more): Infection (65%), allergy (12%), sepsis (11%)

Common (1% to 10%): Neutralizing antibodies

Frequency not reported: Allergic reaction, anaphylactoid reaction

Metabolic

Very common (10% or more): Anorexia (up to 54%), glucose high (41%), weight loss (37%), hyperglycemia (25%), cholesterol high (17%), hypomagnesemia (15%)

Common (1% to 10%): Calcium low, weight gain

Nervous system

Very common (10% or more): Headache (up to 36%), central nervous system disorder (11%), paresthesia (11%)

Frequency not reported: Dizziness

Postmarketing reports: Fainting

Cardiovascular

Very common (10% or more): Hypertension (34%), hemorrhage (up to 29%), pericardial effusion (25%), hypotension (13%), tachycardia (11%)

Postmarketing reports: Arrhythmia, thrombosis

Hepatic

Very common (10% or more): Bilirubinemia (30%), liver damage (13%), ALT increased (13%)

Common (1% to 10%): Alkaline phosphatase increased

Postmarketing reports: Transient liver function abnormalities

Respiratory

Very common (10% or more): Dyspnea (28%), pharyngitis (23%), lung disorder (20%), epistaxis (17%), dyspnea (15%), rhinitis (11%)

Hematologic

Very common (10% or more): Albumin low (27%), blood dyscrasia (25%), thrombocytopenia (19%), leukopenia (17%)

Common (1% to 10%): Agranulocytosis

Frequency not reported: Anemia, serum proteins low, prothrombin time prolonged, progressive increase in circulating monocytes and promonocytes and blasts in the marrow

Postmarketing reports: Eosinophilia

Renal

Very common (10% or more): BUN high (23%), creatinine increased (15%)

Common (1% to 10%): Kidney function abnormal

Musculoskeletal

Very common (10% or more): Bone pain (21%), arthralgia (up to 21%), myalgia (18%)

Common (1% to 10%): Back pain

Postmarketing reports: Joint pain

Genitourinary

Very common (10% or more): Urinary tract disorder (14%)

Common (1% to 10%): Hematuria

Psychiatric

Very common (10% or more): Insomnia (11%), anxiety (11%)

Ocular

Very common (10% or more): Eye hemorrhage (11%)

Local

Postmarketing reports: Injection site reactions

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Leukine