Note: This document contains side effect information about chlorambucil. Some of the dosage forms listed on this page may not apply to the brand name Leukeran.
Applies to chlorambucil: oral tablet
Oral route (Tablet)
Chlorambucil can severely suppress bone marrow function. It is a carcinogen in humans, and is probably mutagenic and teratogenic. Chlorambucil produces human infertility.
Along with its needed effects, chlorambucil (the active ingredient contained in Leukeran) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking chlorambucil:
Incidence not known
Some side effects of chlorambucil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to chlorambucil: compounding powder, oral tablet
Very common (10% or more): Leukopenia, neutropenia, thrombocytopenia, pancytopenia, bone marrow suppression
Common (1% to 10%): Anemia
Very rare (less than 0.01%): Irreversible bone marrow failure
Common (1% to 10%): Convulsions in children with nephrotic syndrome
Rare (0.01% to 0.1%): Convulsions, partial and/or generalized in children and adults, ataxia, flaccid paresis
Very rare (less than 0.01%): Movement disorders (e.g., tremor, muscle twitching, myoclonus in the absence of convulsions, peripheral neuropathy
Uncommon (0.1% to 1%): Rash
Rare (less than 0.1%): Stevens-Johnson syndrome, toxic epidermal necrolysis
Frequency not reported: Urticaria, angioneurotic edema, skin hypersensitivity (including rare reports of skin rash progressing to erythema multiforme)
Common (1% to 10%): Nausea, vomiting, diarrhea, mouth ulceration
Very rare (less than 0.01%): Interstitial pulmonary fibrosis, interstitial pneumonia
Rare (less than 0.1%): Hepatotoxicity, jaundice
Very rare (less than 0.01%): Sterile cystitis
Frequency not reported: Amenorrhea, azoospermia, infertility
Common (1% to 10%): Acute secondary hematologic malignancies (especially leukemia and myelodysplastic syndrome), particularly after long term therapy
Rare (less than 0.1%): Confusion, agitation, hallucinations
Frequency not reported: Tremors, muscular twitching, myoclonia
Rare (less than 0.1%): Pyrexia
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Leukeran