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Lartruvo

Generic Name: olaratumab (OH lar AT ue mab)
Brand Name: Lartruvo
Physician reviewed Lartruvo patient information - includes Lartruvo description, dosage and directions.
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Drug Information:
Lartruvo is a monoclonal antibody that blocks a certain type of cell receptor in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body, which may help slow or stop tumor growth. Lartruvo is used in combination with another cancer medicine called doxorubicin, to treat adults with soft tissue sarcoma. This medicine is used when your condition cannot be treated with surgery or radiation. Lartruvo was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, Lartruvo was shown to lengthen survival time. However, further studies are needed to determine if this medicine is effective in larger numbers of patients with soft tissue sarcoma. Learn more

Lartruvo Side Effects

Lartruvo Side Effects

Note: This document contains side effect information about olaratumab. Some of the dosage forms listed on this page may not apply to the brand name Lartruvo.

For the Consumer

Applies to olaratumab: intravenous solution

Along with its needed effects, olaratumab (the active ingredient contained in Lartruvo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking olaratumab:

More common

  • Back pain
  • blurred vision
  • chest tightness
  • chills
  • confusion
  • cough
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • feeling of warmth
  • fever
  • headache
  • hives, itching, or skin rash
  • nausea and vomiting
  • no blood pressure or pulse
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the face, neck, arms, and occasionally, upper chest
  • stopping of heart
  • sweating
  • tightness in the chest
  • unconsciousness
  • unusual tiredness or weakness

Some side effects of olaratumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • cracked lips
  • decreased appetite
  • diarrhea
  • difficulty with moving
  • dry eyes
  • fear or nervousness
  • hair loss or thinning of the hair
  • muscle pain or stiffness
  • pain in the joints
  • sensation of pins and needles
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth

For Healthcare Professionals

Applies to olaratumab: intravenous solution

General

The most common (20% or greater) adverse reactions of this drug plus doxorubicin are nausea, fatigue, musculoskeletal pain, mucositis, alopecia, vomiting, diarrhea, decreased appetite, abdominal pain, neuropathy, and headache.

Dermatologic

Very common (10% or more): Alopecia (up to 52%)

Gastrointestinal

Very common (10% or more): Nausea (up to 73%), mucositis (up to 53%), vomiting (up to 45%), diarrhea (up to 34%), abdominal pain upper/lower (up to 23%)

Hematologic

Very common (10% or more): Lymphopenia (up to 77%), neutropenia (up to 65%), thrombocytopenia (up to 63%), elevated activated partial thromboplastin time (aPTT) (33%)

Immunologic

Common (1% to 10%): Treatment emergent immunogenicity

Metabolic

Very common (10% or more): Hyperglycemia (up to 52%), appetite decreased (up to 31%), hypokalemia (up to 21%), hypophosphatemia (up to 21%), alkaline phosphatase increased (16%), hypomagnesemia (up to 16%)

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (i.e., arthralgia, back pain, bone pain, flank pain, groin pain, musculoskeletal chest pain, myalgia, muscle spasms, neck pain, pain in extremity) (up to 64%)

Nervous system

Very common (10% or more): Neuropathy (up to 22%), headache (up to 20%)

Ocular

Very common (10% or more): Dry eyes (up to 11%)

Other

Very common (10% or more): Fatigue/asthenia (up to 69%), flushing, fever/chills (up to 14%)

Psychiatric

Very common (10% or more): Anxiety (up to 11%)

Respiratory

Very common (10% or more): Shortness of breath, bronchospasm

Hypersensitivity

Frequency not reported: Anaphylactic shock

Cardiovascular

Frequency not reported: Severe hypotension, cardiac arrest

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Lartruvo