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Generic Name: carfilzomib (kar FILZ oh mib)
Brand Names: Kyprolis
Kyprolis (carfilzomib) is a cancer medication used to treat multiple myeloma. Includes Kyprolis side effects, interactions and indications.
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Drug Information:
Kyprolis (carfilzomib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Kyprolis is used to treat multiple myeloma. It is sometimes given with other medicines when treating relapsed multiple myeloma. Kyprolis is usually given after other treatments have failed. Kyprolis can affect your heart or lungs. Call your doctor at once if you have chest pain, pounding heartbeats, shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet, feeling like you might pass out, wheezing, gasping for breath, cough with foamy mucus, or blue colored appearance of your lips and skin. Learn more

Kyprolis Side Effects

Kyprolis Side Effects

Note: This document contains side effect information about carfilzomib. Some of the dosage forms listed on this page may not apply to the brand name Kyprolis.

In Summary

Common side effects of Kyprolis include: asthenia, arthralgia, dyspnea, fever, thrombocytopenia, vomiting, and chills. Other side effects include: congestive heart failure, pulmonary edema, and reduced ejection fraction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to carfilzomib: intravenous powder for solution

Along with its needed effects, carfilzomib (the active ingredient contained in Kyprolis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking carfilzomib:

More common

  • Agitation
  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • confusion
  • cough
  • decreased awareness or responsiveness
  • decreased urine output
  • depression
  • difficult or labored breathing
  • difficulty with moving
  • dizziness
  • drowsiness
  • fast, slow, or irregular heartbeat
  • headache
  • hoarseness
  • hostility
  • irregular heartbeat
  • irritability
  • loss of consciousness
  • lower back or side pain
  • muscle spasms (tetany) or twitching
  • nausea
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid weight gain
  • seizures
  • severe sleepiness
  • tightness in the chest
  • tingling of the hands or feet
  • trembling
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Less common

  • Chills
  • fever
  • muscle pain or cramps
  • painful blisters on the trunk of the body
  • weakness in the arms, hands, legs, or feet


  • Dark urine
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • light-colored stools
  • stomach pain, continuing
  • thickening of bronchial secretions
  • yellow eyes or skin

Incidence not known

  • Blindness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • joint pain, stiffness, or swelling
  • stomach pain
  • sweating

Some side effects of carfilzomib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • body aches or pain
  • bone pain
  • constipation
  • diarrhea
  • dry mouth
  • ear congestion
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • loss of voice
  • metallic taste
  • muscle weakness
  • pain in the arms or legs
  • runny nose
  • sneezing
  • sore throat
  • trouble sleeping
  • weight loss

For Healthcare Professionals

Applies to carfilzomib: intravenous powder for injection


Very common (10% or more): Anemia (47%), thrombocytopenia (36%), lymphopenia (24%), neutropenia (21%), leukopenia (14%)

Common (1% to 10%): Deep vein thrombosis

Uncommon (0.1% to 1%): Hemolytic uremic syndrome (HUS)

Rare (less than 0.1%): Thrombotic thrombocytopenic purpura (TTP), thrombotic microangiopathy, hemorrhage


Very common (10% or more): Hypertension (14%)

Common (1% to 10%): Cardiac failure (i.e., pulmonary edema, decreased ejection fraction), atrial fibrillation, tachycardia, palpitations, flushing

Uncommon (0.1% to 1%): Cardiac arrest, myocardial infarction, myocardial ischemia, pericarditis, pericardial effusion

Rare (less than 0.1%): Hypertensive crisis


Very common (10% or more): Increased aspartate aminotransferase (13%)

Common (1% to 10%): Increased alanine aminotransferase, increased gamma-glutamyltransferase, hyperbilirubinemia

Uncommon (0.1% to 1%): Hepatic failure, cholestasis

Nervous system

Very common (10% or more): Headache (28%), peripheral neuropathy (14%), dizziness (13%), hypoesthesia (12%), dizziness

Postmarketing reports: Posterior reversible encephalopathy syndrome, paresthesia, hypoesthesia

Uncommon (0.1% to 1%): Intracranial hemorrhage, cerebrovascular accident

Rare (less than 0.1%): Posterior reversible encephalopathy syndrome (PRES)


Very common (10% or more): Fatigue (56%), pyrexia (30%), peripheral edema (24%), chills (16%), arthralgia (16%), asthenia (14%), pain (12%), infusion reaction

Common (1% to 10%): Dysphonia

Uncommon (0.1% to 1%): Multi-organ failure


Very common (10% or more): Dyspnea (35%), upper respiratory tract infection (28%), cough (26%), pneumonia (13%), nasopharyngitis

Common (1% to 10%): Pulmonary hypertension, bronchitis, pulmonary embolism, pulmonary edema, epistaxis, rhinitis, wheezing

Uncommon (0.1% to 1%): Lung infection

Rare (less than 0.1%): Acute respiratory distress syndrome (ARDS), acute respiratory failure, pulmonary hemorrhage, interstitial lung disease, pneumonitis


Very common (10% or more): Nausea (45%), diarrhea (33%), vomiting (22%), constipation (21%), abdominal pain

Common (1% to 10%): Oropharyngeal pain, dyspepsia, toothache

Rare (less than 0.1%): GI hemorrhage, GI perforation


Very common (10% or more): Increased blood creatinine (24%)

Common (1% to 10%): Acute renal failure, renal failure, renal impairment, decreased creatinine renal clearance


Very common (10% or more): Hypokalemia (14%), hypomagnesemia (14%), anorexia (12%), hyperglycemia (12%), hypercalcemia (11%), hypophosphatemia (11%), hyponatremia (10%)

Common (1% to 10%): Dehydration, hyperkalemia, hypocalcemia, hyperuricemia, hypoalbuminemia

Uncommon (0.1% to 1%): Tumor lysis syndrome


Very common (10% or more): Back pain (20%), extremity pain (13%), chest wall pain (11%), arthralgia, muscle spasms

Common (1% to 10%): Musculoskeletal pain, musculoskeletal chest pain, bone pain, myalgia, muscular weakness


Very common (10% or more): Insomnia (17.9%)

Common (1% to 10%): Anxiety


Common (1% to 10%): Herpes zoster reactivation, sepsis, influenza, viral infection


Common (1% to 10%): Rash, pruritus, erythema, hyperhidrosis


Common (1% to 10%): Urinary tract infection


Uncommon (0.1% to 1%): Drug hypersensitivity


Common (1% to 10%): Cataract, blurred vision

Frequency not reported: Blindness and other adverse visual disturbances (due to PRES)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Kyprolis