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Generic Name: anakinra (an na KIN rah)
Brand Names: Kineret
Kineret is used to treat the symptoms of moderate to severe rheumatoid arthritis. Learn about side effects, interactions and indications.
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Drug Information:
Kineret (anakinra) reduces the actions of chemicals in the body that are involved in inflammatory and immune responses. Kineret is used to treat the symptoms of moderate to severe rheumatoid arthritis in adults. It may also help slow the progress of the disease. Kineret is usually given after other arthritis medications have been tried without successful treatment of symptoms. Kineret is also used in newborn babies to treat a rare genetic condition called neonatal onset multisystem inflammatory disease (NOMID). NOMID is a form of cryopyrin-associated periodic syndromes (CAPS). This condition causes uncontrolled inflammation in many parts of the body, including the skin, joints, and central nervous system. Learn more

Kineret Side Effects

Kineret Side Effects

Note: This document contains side effect information about anakinra. Some of the dosage forms listed on this page may not apply to the brand name Kineret.

In Summary

Common side effects of Kineret include: infection, antibody development, and inflammation at injection site. Other side effects include: neutropenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to anakinra: subcutaneous solution

Along with its needed effects, anakinra (the active ingredient contained in Kineret) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking anakinra:

More common

  • Diarrhea
  • fever or chills
  • headache
  • itching, pain, redness, swelling, tenderness or warmth on the skin
  • joint pain
  • muscle aches and pains
  • nausea or vomiting
  • runny nose or sneezing
  • sore throat

Less common or rare

  • Difficulty with swallowing
  • hives, itching, or rash
  • swelling of the face or lips
  • unusual bruising or bleeding
  • unusual tiredness or weakness

Incidence not known

  • Dizziness
  • fast heartbeat
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

Some side effects of anakinra may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty with moving
  • headache
  • muscle aches or stiffness

For Healthcare Professionals

Applies to anakinra: subcutaneous solution


The most serious side effects have included infections and neutropenia, while the most common side effects have included injection site reactions.


Very common (10% or more): Injection site reaction (71%) (including erythema, ecchymosis, inflammation, and pain)


Common (1% to 10%): Neutropenia, decreased total white blood cell count, decreased platelets

Frequency not reported: small increases in the eosinophil differential percentage


Very common (10% or more): Vomiting (14%)

Common (1% to 10%): Nausea, diarrhea, abdominal pain


Very common (10% or more): Upper respiratory tract infection (19%), nasopharyngitis (11%)

Common (1% to 10%): Sinusitis, bronchitis

Nervous system

Very common (10% or more): Headache (12%)


Common (1% to 10%): Arthralgia


Common (1% to 10%): Urinary tract infection


Very common (10% or more): Worsening of RA (19%), pyrexia (11%)


Uncommon (0.1% to 1%): Hepatic enzyme increased

Frequency not reported: Non-infectious hepatitis, elevations of transaminases


Uncommon (0.1% to 1%): Allergic reactions (including anaphylactic reactions), angioedema, urticaria, pruritus

Frequency not reported: Rash


Common (1% to 10%): Serious infections (primarily bacterial) (e.g., cellulitis, pneumonia, bone and joint infections), influenza-like symptoms

Frequency not reported: Development of immunogenicity


Frequency not reported: Increased rate of lymphoma

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Kineret