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Generic Name: lomitapide (loe MI ta pide)
Brand Names: Juxtapid
Juxtapid (lomitapide) is used together with a low-fat diet to lower cholesterol in people with homozygous familial hypercholesterolemia. Includes Juxtapid side effects, interactions and indications.
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Drug Information:
Juxtapid (lomitapide) is a cholesterol-lowering medication. It reduces blood levels of "bad" cholesterol, such as low-density lipoprotein (LDL) or non-high-density liproprotein (non-HDL), as well as a protein that carries bad cholesterol in the blood. Juxtapid is used together with a low-fat diet and other treatments to lower total cholesterol in people with homozygous familial hypercholesterolemia (an inherited type of high cholesterol). It is not known whether Juxtapid will lower your risk of heart disease. Learn more

Juxtapid Side Effects

Juxtapid Side Effects

Note: This document contains side effect information about lomitapide. Some of the dosage forms listed on this page may not apply to the brand name Juxtapid.

In Summary

Common side effects of Juxtapid include: increased serum alanine aminotransferase, increased serum aspartate aminotransferase, abdominal distention, abdominal distress, abdominal pain, constipation, diarrhea, dyspepsia, fever, nausea, vomiting, and flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lomitapide: oral capsule


Oral route (Capsule)

Lomitapide mesylate can cause elevations in transaminases. Measure ALT, AST, alkaline phosphatase, and total bilirubin before initiating treatment and then ALT and AST regularly as recommended. During treatment, adjust the dose of lomitapide mesylate if the ALT or AST is 3 times the ULN or greater. Discontinue lomitapide mesylate for clinically significant liver toxicity. Lomitapide mesylate increases hepatic fat (hepatic steatosis) with or without concomitant increases in transaminases. Hepatic steatosis associated with lomitapide mesylate may be a risk factor for progressive liver disease, including steatohepatitis and cirrhosis. Because of the risk of hepatotoxicity, lomitapide mesylate is available only through a restricted program called the Juxtapid® REMS Program. Prescribe lomitapide mesylate only to patients with a clinical or laboratory diagnosis consistent with homozygous familial hypercholesterolemia (HoFH). The safety and effectiveness of lomitapide mesylate have not been established in patients with hypercholesterolemia who do not have HoFH.

Along with its needed effects, lomitapide (the active ingredient contained in Juxtapid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lomitapide:

More common

  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • dark urine
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • sweating
  • trouble breathing
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of lomitapide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • back pain
  • belching
  • chills
  • constipation
  • cough
  • decreased weight
  • diarrhea
  • dizziness
  • excess air or gas in the stomach or intestines
  • frequent urge to defecate
  • full or bloated feeling
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • indigestion
  • joint pain
  • muscle aches and pains
  • passing gas
  • pressure in the stomach
  • shivering
  • sore throat
  • stomach discomfort, upset, or pain
  • straining while passing stool
  • stuffy or runny nose
  • sweating
  • swelling of the abdominal or stomach area
  • trouble sleeping
  • weakness

For Healthcare Professionals

Applies to lomitapide: oral capsule


Very common (10% or more): Chest pain (24%), angina pectoris (10%), palpitations (10%)


Very common (10% or more): Diarrhea (79%), nausea (65%), dyspepsia (38%), vomiting (34%), abdominal pain (34%), abdominal discomfort (21%), abdominal distention (21%), constipation (21%), flatulence (21%), gastroesophageal reflux disease (10%), defecation urgency ((10%), rectal tenesmus (10%), gastroenteritis (14%)


Very common (10% or more): Increased ALT (17%), at least one elevation in ALT and/or AST greater than or equal to 3 times ULN (29%), hepatic steatosis: of 23 patients in a study for 78 weeks, 18 (78%) exhibited an increase in hepatic fat greater than 5% and 3 (13%) exhibited an increase greater than 20%


Very common (10% or more): Influenza (21%)


Very common (10% or more): Weight loss (24%)

Nervous system

Very common (10% or more): Fatigue (17%), fever (10%), headache (10%), dizziness (10%)


Very common (10% or more): Nasopharyngitis (17%), pharyngolaryngeal pain (14%), nasal congestion (10%)


Common (1% to 10%): Ecchymosis, papule, rash erythematous, xanthoma

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Juxtapid