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Generic Name: cabazitaxel (ka BAZ i TAX el)
Brand Names: Jevtana
Jevtana (cabazitaxel) is used together with prednisone to treat prostate cancer. Includes Jevtana side effects, interactions and indications.
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Drug Information:
Jevtana (cabazitaxel) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Jevtana is used together with prednisone to treat prostate cancer that has spread to other parts of the body (metastatic). Jevtana is usually given after other cancer medicines have been tried without success. You should not use Jevtana if you have severe liver disease, low white blood cell counts, or an allergy to any medicine that contains polysorbate 80. Jevtana can weaken (suppress) your immune system, and you may get an infection or bleed more easily. Jevtana can also cause serious or fatal side effects on your lungs, kidneys, or stomach and intestines. Learn more

Jevtana Side Effects

Jevtana Side Effects

Note: This document contains side effect information about cabazitaxel. Some of the dosage forms listed on this page may not apply to the brand name Jevtana.

In Summary

Common side effects of Jevtana include: neutropenia, diarrhea, nausea, and vomiting. Other side effects include: febrile neutropenia, hypotension, and dehydration. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cabazitaxel: intravenous solution


Intravenous route (Solution)

NeutropeniaNeutropenic deaths have been reported. Monitor for neutropenia with frequent blood cell counts. Cabazitaxel is contraindicated in patients with neutrophil counts of less than or equal to 1500 cells/mm(3). Primary prophylaxis with G-CSF is recommended in patients with high-risk clinical features.Severe HypersensitivitySevere hypersensitivity reactions can occur and may include generalized rash/erythema, hypotension and bronchospasm. Severe hypersensitivity reactions require immediate discontinuation of the cabazitaxel infusion and administration of appropriate therapy. Patients should receive premedication. Cabazitaxel is contraindicated in patients who have a history of severe hypersensitivity reactions to cabazitaxel or to drugs formulated with polysorbate 80.

Along with its needed effects, cabazitaxel (the active ingredient contained in Jevtana) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cabazitaxel:

More common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, numbness, tingling, or painful sensations
  • chest pain
  • chills
  • cough
  • difficult or labored breathing
  • difficult or painful urination
  • fever
  • lower back or side pain
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet

Less common

  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • sweating
  • thirst
  • wrinkled skin

Incidence not known

  • Blue lips, fingernails, or skin
  • burning feeling in the chest or stomach
  • fast breathing
  • frequent urination
  • general feeling of discomfort or illness
  • indigestion
  • lower abdominal cramping
  • nausea
  • severe constipation
  • stomach pain or upset
  • tenderness in the stomach area
  • thickening of bronchial secretions
  • vomiting

Some side effects of cabazitaxel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • change in taste
  • constipation
  • cracked lips
  • decreased weight
  • diarrhea
  • difficulty with swallowing
  • hair loss
  • headache
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • stomach discomfort
  • thinning of the hair
  • weight loss

Less common

  • Back pain
  • difficulty with moving
  • muscle pain, spasm, or stiffness
  • pain in the joints
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed

For Healthcare Professionals

Applies to cabazitaxel: intravenous solution


The most common adverse events were anemia, leukopenia, neutropenia, thrombocytopenia, and diarrhea.


Very common (10% or more): Anemia (98%), leukopenia (96%), neutropenia (94%), thrombocytopenia (48%)

Common (1% to 10%): Febrile neutropenia


Very common (10% or more): Diarrhea (47%), nausea (34%), vomiting (22%), constipation (20%), abdominal pain (17%), dyspepsia (10%)

Common (1% to 10%): Abdominal pain upper, hemorrhoids, gastroesophageal reflux disease, rectal hemorrhage, dry mouth, abdominal distension

Frequency not reported: Death related to diarrhea and electrolyte imbalance, GI hemorrhage and perforation, ileus, enterocolitis, neutropenic enterocolitis, colitis

Postmarketing reports: Gastritis, intestinal obstruction

Nervous system

Very common (10% or more): Fatigue (37%), dysgeusia (11%)

Common (1% to 10%): Dizziness, peripheral neuropathy, headache, peripheral sensory neuropathy, paresthesia, lethargy, hypoesthesia, tinnitus, vertigo, sciatica

Frequency not reported: Peripheral motor neuropathy, fatal cerebral hemorrhage


Very common (10% or more): Asthenia (20%), pyrexia (12%)

Common (1% to 10%): Mucosal inflammation, pain, death due to causes other than disease progression, malaise


Very common (10% or more): Dyspnea (12%), cough (11%)

Common (1% to 10%): Oropharyngeal pain


Common (1% to 10%): Peripheral edema, arrhythmia, hypotension, deep vein thrombosis, hypertension, tachycardia, grade 3 or higher arrhythmias, orthostatic hypotension, hot flush, flushing, atrial fibrillation

Uncommon (0.1% to 1%): Cardiac failure, cardiac arrest, fatal ventricular fibrillation


Uncommon (0.1% to 1%): Grade 3 to 4 increased AST, grade 3 to 4 increased ALT, increased bilirubin

Frequency not reported: Fatal renal failure


Very common (10% or more): Anorexia (16%)

Common (1% to 10%): Weight decreased, dehydration, edema, hyperglycemia, hypokalemia


Very common (10% or more): Hematuria (17%)

Common (1% to 10%): Dysuria, pollakiuria, urinary retention, urinary incontinence, ureteric obstruction, pelvic pain


Common (1% to 10%): AST increased, transaminases increased

Uncommon (0.1% to 1%): ALT increased, bilirubin increased


Common (1% to 10%): Hypersensitivity


Very common (10% or more): Back pain (16%), arthralgia (10.5%)

Common (1% to 10%): Pain in extremity, muscle spasms, myalgia, musculoskeletal chest pain, flank pain, chills


Common (1% to 10%): Urinary tract infection, influenza, cystitis, upper respiratory tract infection, pneumonia, cellulitis, herpes zoster, septic shock, sepsis, candidiasis

Uncommon (0.1% to 1%): Neutropenic sepsis, neutropenic infections

Frequency not reported: Fatal infection


Very common (10% or more): Alopecia (10%)

Common (1% to 10%): Dry skin, erythema


Common (1% to 10%): Conjunctivitis, increased lacrimation


Common (1% to 10%): Anxiety, confusional state

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Jevtana