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Generic Name: ruxolitinib (RUX oh LI ti nib)
Brand Names: Jakafi
Jakafi (ruxolitinib) is used to treat myelofibrosis, polycythemia vera, and graft versus host disease. Includes Jakafi side effects, interactions and indications.
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Drug Information:
Jakafi (ruxolitinib) works by blocking certain enzymes in the body that affect blood cell production. Jakafi is used to treat myelofibrosis or polycythemia vera, which are bone marrow disorders that that affect your body's ability to produce blood cells. Jakafi is also used to treat acute graft versus host disease (GVHD) in adults and children 12 years of age and older who have taken corticosteroids and they did not work well enough. Jakafi may also be used for purposes not listed in this medication guide. Learn more

Jakafi Side Effects

Jakafi Side Effects

Note: This document contains side effect information about ruxolitinib. Some of the dosage forms listed on this page may not apply to the brand name Jakafi.

In Summary

Common side effects of Jakafi include: anemia, balance impairment, dizziness, headache, labyrinthitis, meniere's disease, neutropenia, thrombocytopenia, vertigo, and orthostatic dizziness. Other side effects include: weight gain, and flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ruxolitinib: oral tablet

Along with its needed effects, ruxolitinib (the active ingredient contained in Jakafi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ruxolitinib:

More common

  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • blood in the urine or stools
  • bruising
  • chills
  • cloudy urine
  • collection of blood under the skin
  • cough
  • deep, dark purple bruise
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • itching, pain, redness, or swelling
  • large, flat, blue or purplish patches in the skin
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • pus in the urine
  • shortness of breath
  • small, red or purple spots on the skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Painful blisters on the trunk of the body

Some side effects of ruxolitinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloated or full feeling
  • dizziness or lightheadedness
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • headache
  • passing gas
  • sensation of spinning
  • weight gain

For Healthcare Professionals

Applies to ruxolitinib: oral tablet


Very common (10% or more): Bruising (up to 23.2%)

Common (1% to 10%): Herpes zoster


Common (1% to 10%): Flatulence, gastrointestinal bleeding


Very common (10% or more): Urinary tract infection (up to 14.4%)


Very common (10% or more): Anemia (up to 96.1%), thrombocytopenia (up to 69.8%), neutropenia (up to 18.7%)


Common (1% to 10%): Tuberculosis

Frequency not reported: Progressive multifocal leukoencephalopathy


Very common (10% or more): Hypercholesterolemia (up to 17.4%), weight gain (up to 10%)

Nervous system

Very common (10% or more): Dizziness (up to 18.1%), headache (up to 14.8%)

Common (1% to 10%): Intracranial bleeding


The most common adverse reactions were anemia, thrombocytopenia, bruising, dizziness, and headache.


Very common (10% or more): Bleeding (up to 32.6%)


Very common (10% or more): ALT increased (up to 27.1%), AST increased (up to 19.3%)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Jakafi